In 2011, we finished work on a long-term project that aimed to provide in vitro and in vivo evidence for a role of S. epidermidis phenol-soluble modulin peptides (PSMs) in the structuring and detachment of S. epidermidis biofilms. These mechanisms are believed to be crucial for the development and dissemination of staphylococcal biofilm-related infection. Furthermore, we investigated mechanisms by which S. epidermidis evades killing by human neutrophils, with a focus on PSM peptides (in collaboration with Dr. DeLeo). In several further collaborative efforts, we investigated the role of S. epidermidis in prosthetic joint infection (with Dr. Kreiswirth) and the role of the ygs gene in the general stress response of S. epidermidis (with Dr. Gao)
| Zheng, Yue; He, Lei; Asiamah, Titus K et al. (2018) Colonization of medical devices by staphylococci. Environ Microbiol 20:3141-3153 |
| Nakatsuji, Teruaki; Chen, Tiffany H; Butcher, Anna M et al. (2018) A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv 4:eaao4502 |
| Le, Katherine Y; Park, Matthew D; Otto, Michael (2018) Immune Evasion Mechanisms of Staphylococcus epidermidis Biofilm Infection. Front Microbiol 9:359 |
| Da, Fei; Joo, Hwang-Soo; Cheung, Gordon Y C et al. (2017) Phenol-Soluble Modulin Toxins of Staphylococcus haemolyticus. Front Cell Infect Microbiol 7:206 |
| Otto, Michael (2017) Staphylococcus epidermidis: a major player in bacterial sepsis? Future Microbiol 12:1031-1033 |
| Nguyen, Thuan H; Park, Matthew D; Otto, Michael (2017) Host Response toStaphylococcus epidermidisColonization and Infections. Front Cell Infect Microbiol 7:90 |
| Qin, Li; Da, Fei; Fisher, Emilie L et al. (2017) Toxin Mediates Sepsis Caused by Methicillin-Resistant Staphylococcus epidermidis. PLoS Pathog 13:e1006153 |
| Qin, Li; McCausland, Joshua W; Cheung, Gordon Y C et al. (2016) PSM-Mec-A Virulence Determinant that Connects Transcriptional Regulation, Virulence, and Antibiotic Resistance in Staphylococci. Front Microbiol 7:1293 |
| Joo, Hwang-Soo; Fu, Chih-Iung; Otto, Michael (2016) Bacterial strategies of resistance to antimicrobial peptides. Philos Trans R Soc Lond B Biol Sci 371: |
| Li, Tianming; He, Lei; Song, Yan et al. (2016) AraC-Type Regulator Rsp Adapts Staphylococcus aureus Gene Expression to Acute Infection. Infect Immun 84:723-34 |
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