Abstract

In FY 2013, we continued our efforts to understand the impact that phenol-soluble modulins have on biofilm development. We have shown the contribution of beta-type PSMs to S. epidermidis biofilm development and all PSMs to S. aureus biofilm development in recent papers in recent papers (Wang et al. J Clin Invest 2011, Periasamy et al. PNAS 2012). We are now trying to complete our set of isogenic deletion mutants in S. epidermidis psm loci to investigate the role all PSMs play in S. epidermidis biofilm development and dissemination from device-related infection in vivo.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI001080-06
Application #
8745512
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2013
Total Cost
$252,853
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Zheng, Yue; He, Lei; Asiamah, Titus K et al. (2018) Colonization of medical devices by staphylococci. Environ Microbiol 20:3141-3153
Nakatsuji, Teruaki; Chen, Tiffany H; Butcher, Anna M et al. (2018) A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv 4:eaao4502
Le, Katherine Y; Park, Matthew D; Otto, Michael (2018) Immune Evasion Mechanisms of Staphylococcus epidermidis Biofilm Infection. Front Microbiol 9:359
Da, Fei; Joo, Hwang-Soo; Cheung, Gordon Y C et al. (2017) Phenol-Soluble Modulin Toxins of Staphylococcus haemolyticus. Front Cell Infect Microbiol 7:206
Otto, Michael (2017) Staphylococcus epidermidis: a major player in bacterial sepsis? Future Microbiol 12:1031-1033
Nguyen, Thuan H; Park, Matthew D; Otto, Michael (2017) Host Response toStaphylococcus epidermidisColonization and Infections. Front Cell Infect Microbiol 7:90
Qin, Li; Da, Fei; Fisher, Emilie L et al. (2017) Toxin Mediates Sepsis Caused by Methicillin-Resistant Staphylococcus epidermidis. PLoS Pathog 13:e1006153
Qin, Li; McCausland, Joshua W; Cheung, Gordon Y C et al. (2016) PSM-Mec-A Virulence Determinant that Connects Transcriptional Regulation, Virulence, and Antibiotic Resistance in Staphylococci. Front Microbiol 7:1293
Joo, Hwang-Soo; Fu, Chih-Iung; Otto, Michael (2016) Bacterial strategies of resistance to antimicrobial peptides. Philos Trans R Soc Lond B Biol Sci 371:
Li, Tianming; He, Lei; Song, Yan et al. (2016) AraC-Type Regulator Rsp Adapts Staphylococcus aureus Gene Expression to Acute Infection. Infect Immun 84:723-34

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