In FY 2013, we continued our efforts to understand the impact that phenol-soluble modulins have on biofilm development. We have shown the contribution of beta-type PSMs to S. epidermidis biofilm development and all PSMs to S. aureus biofilm development in recent papers in recent papers (Wang et al. J Clin Invest 2011, Periasamy et al. PNAS 2012). We are now trying to complete our set of isogenic deletion mutants in S. epidermidis psm loci to investigate the role all PSMs play in S. epidermidis biofilm development and dissemination from device-related infection in vivo.

Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2013
Total Cost
$252,853
Indirect Cost
City
State
Country
Zip Code
Joo, Hwang-Soo; Fu, Chih-Iung; Otto, Michael (2016) Bacterial strategies of resistance to antimicrobial peptides. Philos Trans R Soc Lond B Biol Sci 371:
Li, Tianming; He, Lei; Song, Yan et al. (2016) AraC-Type Regulator Rsp Adapts Staphylococcus aureus Gene Expression to Acute Infection. Infect Immun 84:723-34
Joo, Hwang-Soo; Otto, Michael (2015) Mechanisms of resistance to antimicrobial peptides in staphylococci. Biochim Biophys Acta 1848:3055-61
Dastgheyb, Sana S; Otto, Michael (2015) Staphylococcal adaptation to diverse physiologic niches: an overview of transcriptomic and phenotypic changes in different biological environments. Future Microbiol 10:1981-95
Dastgheyb, Sana; Parvizi, Javad; Shapiro, Irving M et al. (2015) Effect of biofilms on recalcitrance of staphylococcal joint infection to antibiotic treatment. J Infect Dis 211:641-50
Dastgheyb, Sana; Hickok, Noreen J; Otto, Michael (2015) Reply to Perez and Patel. J Infect Dis 212:336-7
Le, Katherine Y; Otto, Michael (2015) Quorum-sensing regulation in staphylococci-an overview. Front Microbiol 6:1174
Dastgheyb, Sana S; Villaruz, Amer E; Le, Katherine Y et al. (2015) Role of Phenol-Soluble Modulins in Formation of Staphylococcus aureus Biofilms in Synovial Fluid. Infect Immun 83:2966-75
Dastgheyb, Sana S; Hammoud, Sommer; Ketonis, Constantinos et al. (2015) Staphylococcal persistence due to biofilm formation in synovial fluid containing prophylactic cefazolin. Antimicrob Agents Chemother 59:2122-8
Scharschmidt, Tiffany C; Vasquez, Kimberly S; Truong, Hong-An et al. (2015) A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes. Immunity 43:1011-21

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