The isolation and characterization of MPCs from human traumatized tissue obtained during wound debridements represents a valuable advance. This has allowed defining the characteristics of these cells and the potential factors involved in the development of heterotropic ossification. This may provide an understanding of the role of MPCs in wound repair and/or complications advancing the mechanistic knowledge in how MPCs are involved in the wound healing process. The overall effect of these ongoing studies would be to improve our understanding of the underlying mechanisms behind these potentially debilitating traumatic wound complications.
| Jackson, Wesley M; Alexander, Peter G; Bulken-Hoover, Jamie D et al. (2013) Mesenchymal progenitor cells derived from traumatized muscle enhance neurite growth. J Tissue Eng Regen Med 7:443-51 |
| Jackson, Wesley M; Nesti, Leon J; Tuan, Rocky S (2012) Mesenchymal stem cell therapy for attenuation of scar formation during wound healing. Stem Cell Res Ther 3:20 |
| Kluk, Matthew W; Ji, Youngmi; Shin, Emily H et al. (2012) Fibroregulation of mesenchymal progenitor cells by BMP-4 after traumatic muscle injury. J Orthop Trauma 26:693-8 |
| Bulken-Hoover, Jamie D; Jackson, Wesley M; Ji, Youngmi et al. (2012) Inducible expression of neurotrophic factors by mesenchymal progenitor cells derived from traumatically injured human muscle. Mol Biotechnol 51:128-36 |
| Nauth, Aaron; Giles, Erica; Potter, Benjamin K et al. (2012) Heterotopic ossification in orthopaedic trauma. J Orthop Trauma 26:684-8 |
| Jackson, Wesley M; Nesti, Leon J; Tuan, Rocky S (2012) Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells. Stem Cells Transl Med 1:44-50 |
| Christopherson, Gregory T; Nesti, Leon J (2011) Stem cell applications in military medicine. Stem Cell Res Ther 2:40 |
| Ji, Youngmi; Christopherson, Gregory T; Kluk, Matthew W et al. (2011) Heterotopic ossification following musculoskeletal trauma: modeling stem and progenitor cells in their microenvironment. Adv Exp Med Biol 720:39-50 |
| Jackson, Wesley M; Lozito, Thomas P; Djouad, Farida et al. (2011) Differentiation and regeneration potential of mesenchymal progenitor cells derived from traumatized muscle tissue. J Cell Mol Med 15:2377-88 |
| Jackson, Wesley M; Aragon, Amber B; Onodera, Jun et al. (2011) Cytokine expression in muscle following traumatic injury. J Orthop Res 29:1613-20 |
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