Adoptive immunotherapy for cancer: building on success Substantial progress has been made in our understanding of the molecular and cellular bases of T cell mediated anti-tumor responses. T cells are potent effectors of the adaptive anti-tumor immune response. Some target antigens recognized by tumor-reactive CD8+ T cells are non-mutated self-antigens that are also expressed by tumor cells. The molecular signals that modulate T cell activation, function and memory are being elucidated. Both positive and negative signals from co-stimulatory molecules have been shown to shape the anti-tumor response. Cytokines, including those with receptors that contain the common cytokine-receptor gamma chain have been shown to alter the programming of effector CD8+ T cells.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC010763-08
Application #
8763203
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2013
Total Cost
$1,302,115
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Roychoudhuri, Rahul; Eil, Robert L; Clever, David et al. (2016) The transcription factor BACH2 promotes tumor immunosuppression. J Clin Invest 126:599-604
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Crompton, Joseph G; Sukumar, Madhusudhanan; Roychoudhuri, Rahul et al. (2015) Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics. Cancer Res 75:296-305
Ya, Zhiya; Hailemichael, Yared; Overwijk, Willem et al. (2015) Mouse model for pre-clinical study of human cancer immunotherapy. Curr Protoc Immunol 108:20.1.1-43
Beane, Joal D; Lee, Gary; Zheng, Zhili et al. (2015) Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma. Mol Ther 23:1380-90
Roychoudhuri, Rahul; Lefebvre, Francois; Honda, Mitsuo et al. (2015) Transcriptional profiles reveal a stepwise developmental program of memory CD8(+) T cell differentiation. Vaccine 33:914-23

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