Abstract

This is a new lab starting in January of 2009. We are in a process to produce and breed mouse colonies in which TGFbeta R2 receptor is specifically deleted in tumor cells or host immature myeloid cells. During this short time we have established all technical procedures needed for this project. A new postdoc is hired with 100% effort devoted to dissecting the underlying mechanisms of inflammation in TGFbeta signaling in breast cancer progression. We have obtained preliminary data supporting our hypothesis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011163-01
Application #
7966136
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2009
Total Cost
$547,556
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Yan, Hangyi H; Jiang, Jian; Pang, Yanli et al. (2015) CCL9 Induced by TGF? Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ. Cancer Res 75:5283-98
Pang, Yanli; Gara, Sudheer Kumar; Achyut, Bhagelu R et al. (2013) TGF-? signaling in myeloid cells is required for tumor metastasis. Cancer Discov 3:936-51
Luger, Dror; Yang, Yu-An; Raviv, Asaf et al. (2013) Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects. PLoS One 8:e76115
Yang, Li; Edwards, Claire M; Mundy, Gregory R (2010) Gr-1+CD11b+ myeloid-derived suppressor cells: formidable partners in tumor metastasis. J Bone Miner Res 25:1701-6
Yang, L (2010) TGFbeta, a potent regulator of tumor microenvironment and host immune response, implication for therapy. Curr Mol Med 10:374-80
Hembruff, Stacey L; Jokar, Iman; Yang, Li et al. (2010) Loss of transforming growth factor-beta signaling in mammary fibroblasts enhances CCL2 secretion to promote mammary tumor progression through macrophage-dependent and -independent mechanisms. Neoplasia 12:425-33
Yang, Li (2010) TGFbeta and cancer metastasis: an inflammation link. Cancer Metastasis Rev 29:263-71
Yang, Li; Pang, Yanli; Moses, Harold L (2010) TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol 31:220-7