Following up on prior work that identified the perineural microenvironment as a regulator of hair follicle stem cells, we have completed a project describing a perivascular niche for hair follicle stem cells. Moreover, we have identified that sensory touch domes in the skin, and the Merkel cells housed there are also regulated by associated sensory neurons. We have continued experiments demonstrating that touch domes are a novel and distinct cell lineage within the skin maintained by their own stem cell population. We have also investigated the developmental requirements for Merkel cell formation in skin.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011393-03
Application #
8763488
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2013
Total Cost
$540,286
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Xiao, Ying; Thoresen, Daniel T; Miao, Lingling et al. (2016) A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development. PLoS Genet 12:e1006150
Peterson, Shelby C; Brownell, Isaac; Wong, Sunny Y (2016) Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease. J Vis Exp :
Xiao, Ying; Thoresen, Daniel T; Williams, Jonathan S et al. (2015) Neural Hedgehog signaling maintains stem cell renewal in the sensory touch dome epithelium. Proc Natl Acad Sci U S A 112:7195-200
Williams, Jonathan S; Xiao, Ying; Brownell, Isaac (2014) Low pH reprograms somatic murine cells into pluripotent stem cells: a novel technique with therapeutic implications. Cancer Biol Ther 15:675-7
Xiao, Ying; Woo, Wei-Meng; Nagao, Keisuke et al. (2013) Perivascular hair follicle stem cells associate with a venule annulus. J Invest Dermatol 133:2324-31
Brownell, Isaac; Guevara, Elizabeth; Bai, C Brian et al. (2011) Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells. Cell Stem Cell 8:552-65