In a preliminary study, we have identified unique signatures for each histologic subtype of kidney tumors. Expression values for downregulated miRNAs ranged from 0.3-fold (in VHL-clear cell RCC) up to 0.393 fold (in Pap-II HLRCC tumors). Commonly lost miRNAs in clear cell tumors (both sporadic and clear cell) included miR-184 and miR-206, while miR-122 and -143 were the most commonly downregulated in Papillary type I tumors.Our data supports the hypothesized involvement of miR-92a and miR-210 in clear cell tumors. ccRCC expressed increased amount of miR92a and these tumors showed decreased levels of VHL mRNA, supporting the concept that microRNAs may influence transcript abundance of protein-coding target genes in RCC.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
National Cancer Institute Division of Basic Sciences
Zip Code
Alimchandani, Meghna; Lara, Karlena; Tsokos, Maria et al. (2014) Lymphangitic retroperitoneal carcinomatosis occurring from metastatic sarcomatoid chromophobe renal cell carcinoma. Urol Case Rep 2:39-62
Shuch, Brian; Vourganti, Srinivas; Ricketts, Christopher J et al. (2014) Defining early-onset kidney cancer: implications for germline and somatic mutation testing and clinical management. J Clin Oncol 32:431-7
Diker-Cohen, Talia; Abraham, Smita Baid; Rauschecker, Mitra et al. (2014) Reninoma presenting in pregnancy. J Clin Endocrinol Metab 99:2625-6
Kauffman, Eric C; Ricketts, Christopher J; Rais-Bahrami, Soroush et al. (2014) Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers. Nat Rev Urol 11:465-75
Zhong, Minghao; Weisman, Paul; Zhu, Bing et al. (2013) Xp11.2 translocation renal cell carcinoma with PSF-TFE3 rearrangement. Diagn Mol Pathol 22:107-11
Shuch, Brian; Ricketts, Christopher J; Vocke, Cathy D et al. (2013) Germline PTEN Mutation Cowden Syndrome: An Underappreciated Form of Hereditary Kidney Cancer. J Urol :
Aung, Phyu P; Killian, Keith; Poropatich, Carrie O et al. (2013) Primary neuroendocrine tumors of the kidney: morphological and molecular alterations of an uncommon malignancy. Hum Pathol 44:873-80