This project aims to complete a total synthesis of a recently isolated natural product.
We aim to complete the synthesis in a minimum number of steps, while developing a flexible route that will enable the production of significant quantities of the natural product. Furthermore, this work will enable access to analogs and model compounds that will enable the understanding of structure-activity relationships, as well as the mode of binding to the ligase. For example, we believe that this molecule may be a cysteine-reactive compound. A total synthesis effort will enable us to generate "deletion analogs" lacking specific functional groups, as well as biotinylated or fluorescent affinity/imaging probes that will be critical for understanding the molecular mechanism of action. We have made significant progress toward completing the synthesis, and plan to make contributions to the biology side of this project in the near future.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011451-01
Application #
8553196
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2012
Total Cost
$378,957
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code