Metastatic or unresectable disease is the direct or indirect cause of 90% of all cancer deaths, and curative therapies for the treatment of metastatic cancers are rare. My ultimate goal is to develop methods that that enable us to achieve systemic tumor control after localized irradiation, when localized radiation therapy is indicated. There are no broadly effective systemic therapies for the treatment of metastatic soft tissue sarcomas, but localized palliative radiation therapy is commonly used and provides a therapeutic opportunity if an anti-tumor immune response is induced by immunotherapies administered at the time of the palliative radiation. Combining radiation with immunotherapy is a promising method for treating metastatic malignancies, and we hypothesized that the effects of radiation (RT) on immune cells in the tumor microenvironment will determine the utility of different immunotherapeutic (IT) methods in RT + IT combination therapies. We are identifying immunotherapies that combine effectively with radiation to promote systemic immune-mediated regression of metastatic disease.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011503-01
Application #
8763573
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2013
Total Cost
$36,878
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Parker, Jennifer J; Jones, Jennifer C; Strober, Samuel et al. (2013) Characterization of direct radiation-induced immune function and molecular signaling changes in an antigen presenting cell line. Clin Immunol 148:44-55
Fasola, Carolina E; Jones, Jennifer C; Huang, Derek D et al. (2013) Low-dose radiation therapy (2 Gy ýý 2) in the treatment of orbital lymphoma. Int J Radiat Oncol Biol Phys 86:930-5