Urban Health Study (CAS 10067) The Urban Health Study is a human population-based, community-based, etiologic study of 2,400 San Francisco Bay area injection drug users who are exposed to a variety of blood borne viruses. The viruses of most interest cause hepatocellular carcinoma, non-Hodgkin lymphoma, cirrhosis and end-stage liver disease. This research has a molecular component: the specimens are being used to investigate gene markers that may be associated with disease. We make genetic comparisons between drug users who failed to become infected with HCV and otherwise similar HCV-infected subjects. We will also compare subjects who are chronically infected with HBV or HCV to those with resolved infection. HALT-C Study (CAS 10070) This study makes use of data and specimens that were collected from patients with chronic hepatitis C during the HALT-C trial, which evaluated the efficacy of long-term treatment with pegylated interferon plus ribavirin to prevent hepatocellular carcinoma and cirrhosis. We compare host genetic polymorphisms in HALT-C non-responders to HALT-C participants who responded to anti-viral treatment. This is a human population-based study in a clinical setting. This research has a molecular component in that DNA specimens are used to investigate gene markers that may be associated with treatment response. This study aims to detect genetic markers that make patients more likely to respond to anti-viral treatment and, therefore, less likely to develop hepatocellular carcinoma. HCC in the United States (CAS 10303) This study is human population-based and etiologic. The study setting is clinical and it includes patients with chronic HCV infection who are undergoing liver transplantation. This research has a molecular component in that specimens are being used to investigate genetic markers (liver gene expression) that may be associated with the development of hepatocellular carcinoma and cirrhosis. Human Immunodeficiency Virus Epidemiology Research Study (HERS) (CAS 10426) This research project is human population-based and etiologic The study setting is clinical and it is focused on infection with HIV, which causes non-Hodgkin lymphoma and Kaposi sarcoma. This research has a molecular component- specimens are being used to investigate gene markers that may be associated with HIV infection.

National Institute of Health (NIH)
National Cancer Institute (NCI)
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Division of Cancer Epidemiology and Genetics
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O'Brien, Thomas R; Pfeiffer, Ruth M; Paquin, Ashley et al. (2015) Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance. J Hepatol 63:1103-10
Uccellini, Lorenzo; Tseng, Fan-Chen; Monaco, Alessandro et al. (2012) HCV RNA levels in a multiethnic cohort of injection drug users: human genetic, viral and demographic associations. Hepatology 56:86-94
Abu Dayyeh, Barham K; Yang, May; Fuchs, Bryan C et al. (2011) A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma. Gastroenterology 141:141-9
Morgan, Timothy R; O'Brien, Thomas R (2011) IL28B-genotype testing now and in the era of direct-acting antiviral agents. Clin Gastroenterol Hepatol 9:293-4
Shebl, Fatma M; Pfeiffer, Ruth M; Buckett, Dianna et al. (2011) IL28B rs12979860 genotype and spontaneous clearance of hepatitis C virus in a multi-ethnic cohort of injection drug users: evidence for a supra-additive association. J Infect Dis 204:1843-7
O'Brien, Thomas R (2011) Editorial: epidemic-assistance investigations by the centers for disease control and prevention: the first 60 years. Am J Epidemiol 174:1211-2
O'Brien, Thomas R; Everhart, James E; Morgan, Timothy R et al. (2011) An IL28B genotype-based clinical prediction model for treatment of chronic hepatitis C. PLoS One 6:e20904
O'Brien, T R; Kohaar, I; Pfeiffer, R M et al. (2011) Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver. Genes Immun 12:428-33
Bekker, V; Chanock, S J; Yeager, M et al. (2010) Genetic variation in CLDN1 and susceptibility to hepatitis C virus infection. J Viral Hepat 17:192-200
Bekker, Vincent; O'Brien, Thomas R; Chanock, Stephen (2009) Population genetics and comparative genetics of CLDN1, a gene involved in hepatitis C virus entry. Hum Hered 67:206-16