SUCCEED directed by Dr. Wentzensen is a cross-sectional study among women referred for abnormal cevrical cancer screening results focused on the identification of biomarkers of risk at each progressive disease stage, aimed to identify the molecular events that are necessary and sufficient for progression to cervical cancer. Frozen specimens, often multiple, from 2,500 women with varying grades of cervical neoplasia (including the ectocervix, transformation zone, and endocervix) have already been collected. In a new study, the Biopsy Study conducted at the same center in Oklahoma, Dr. Wentzensen is investigating the earliest discernible transitions from HPV infection to CIN3 and the best methods for colposcopic detection of CIN3 to improve current cervical cancer prevention strategies. The ALTS clinical trial evaluated management options for women with abnormal cervical cancer screening results and has been completed several years ago. The specimens collected in women with minor cytological abnormalities and 2 year follow up still serve as an important resource to evaluate HPV tests and novel biomarkers, such as viral methylation. The Anal Cancer Screening Study in HIV positive men who have sex with men is conducted with Kaiser Permanente Northern California to identify the HPV genotype attribution in anal precancer and to study biomarkers for anal cancer screening The Intramural to India project is a new effort to study cervical cancer precursors among HIV-infected women in India. The case control study of invasive cervical cancer in four Latin-American countries is an important resource to study sero-epidemiologic markers of cervical cancer risk.

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National Cancer Institute (NCI)
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Bodelon, Clara; Vinokurova, Svetlana; Sampson, Joshua N et al. (2016) Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer. Carcinogenesis 37:188-96
Schiffman, Mark; Wentzensen, Nicolas (2016) A Suggested Approach to Simplify and Improve Cervical Screening in the United States. J Low Genit Tract Dis 20:1-7
Hildesheim, Allan; Gonzalez, Paula; Kreimer, Aimee R et al. (2016) Impact of human papillomavirus (HPV) 16 and 18 vaccination on prevalent infections and rates of cervical lesions after excisional treatment. Am J Obstet Gynecol 215:212.e1-212.e15
Liu, Angela H; Gold, Michael A; Schiffman, Mark et al. (2016) Comparison of Colposcopic Impression Based on Live Colposcopy and Evaluation of Static Digital Images. J Low Genit Tract Dis 20:154-61
van Baars, Romy; van der Marel, Jacolien; Snijders, Peter J F et al. (2016) CADM1 and MAL methylation status in cervical scrapes is representative of the most severe underlying lesion in women with multiple cervical biopsies. Int J Cancer 138:463-71
Xu, Lan; Verdoodt, Freija; Wentzensen, Nicolas et al. (2016) Triage of ASC-H: A meta-analysis of the accuracy of high-risk HPV testing and other markers to detect cervical precancer. Cancer Cytopathol 124:261-72
Wentzensen, Nicolas; Walker, Joan L; Gold, Michael A et al. (2015) Multiple biopsies and detection of cervical cancer precursors at colposcopy. J Clin Oncol 33:83-9
den Boon, Johan A; Pyeon, Dohun; Wang, Sophia S et al. (2015) Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling. Proc Natl Acad Sci U S A 112:E3255-64
van der Marel, Jacolien; Berkhof, Johannes; Ordi, Jaume et al. (2015) Attributing oncogenic human papillomavirus genotypes to high-grade cervical neoplasia: which type causes the lesion? Am J Surg Pathol 39:496-504
van der Marel, Jacolien; Rodriguez, Agata; Del Pino, Marta et al. (2015) The Value of Endocervical Curettage in Addition to Biopsies in Women Referred to Colposcopy. J Low Genit Tract Dis 19:282-287

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