10513 - To oversee the field support and computer support contracts responsible for annual follow-up of study subjects from the PLCO trial and construct analyzable data sets for use by investigators throughout the division. The Division of Cancer Prevention (DCP, formerly DCPC), under extramural contracts to 10 U.S. clinical centers, is evaluating the effectiveness of screening for prostate, lung, colorectal and ovarian cancer (The PLCO Trial). In 1996 the NCI Executive Committee approved the expansion of the PLCO Trial to collect additional materials and to conduct additional studies. About, 74,000 men and 74,000 women, aged 55-74 years, have been randomized on a 50/50 basis into screening or usual care arms. Additional blood is collected from screened subjects and saliva for buccal cells from control subjects. Pathologic tissues are obtained for selected cases that develop cancer or selected related diseases (e.g. colon polyps, benign prostatic hyperplasia). Additional questionnaire-based risk and disease-related information is also collected, with confirmation of disease status from medical records. Genetic, biochemical and questionnaire-based risk information will be related to the development of cancer and other diseases in this population. Volunteers who provide samples for these studies will not routinely receive their individual results from the Additional Investigation. Subjects requesting such information, however, will be provided their test results. In 2009 the NCI Executive Committee approved the Extended Follow-up of subjects beyond the original 13-year follow-up period. Participants will be reconsented for the release of records to a single NCI-Designated Central Data Collection Center (CDCC), which will administer the annual mailings containing the annual study update questionnaire and a brief (1-2 page) risk factor questionnaire. Individuals who do not consent to release their identifiers to the CDCC will be followed up passively through linkage to state cancer registries and the National Death Index. l Death Index.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010207-04
Application #
8763650
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2013
Total Cost
$761,919
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Peters, Brandilyn A; Wu, Jing; Pei, Zhiheng et al. (2017) Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers. Cancer Res 77:6777-6787
Pinsky, P F; Yu, K; Black, A et al. (2016) Active follow-up versus passive linkage with cancer registries for case ascertainment in a cohort. Cancer Epidemiol 45:26-31
Zhu, Claire S; Huang, Wen-Yi; Pinsky, Paul F et al. (2016) The Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) Screening Trial Pathology Tissue Resource. Cancer Epidemiol Biomarkers Prev 25:1635-1642
Pinsky, Paul F; Yu, Kelly; Kramer, Barnett S et al. (2016) Extended mortality results for ovarian cancer screening in the PLCO trial with median 15years follow-up. Gynecol Oncol 143:270-275
Black, Amanda; Huang, Wen-Yi; Wright, Patrick et al. (2015) PLCO: Evolution of an Epidemiologic Resource and Opportunities for Future Studies. Rev Recent Clin Trials 10:238-45
Black, Amanda; Pinsky, Paul F; Grubb 3rd, Robert L et al. (2014) Sex steroid hormone metabolism in relation to risk of aggressive prostate cancer. Cancer Epidemiol Biomarkers Prev 23:2374-82
Black, Amanda; Gibson, Todd M; Shiels, Meredith S et al. (2014) Pooling prospective studies to investigate the etiology of second cancers. Cancer Epidemiol Biomarkers Prev 23:1598-608
Black, Amanda; Berg, Christine D (2012) Prostate-specific antigen screening for prostate cancer in older men in the United States of America. Gerontology 58:331-6
Buys, Saundra S; Partridge, Edward; Black, Amanda et al. (2011) Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. JAMA 305:2295-303