High rates of relapse to drug use after prolonged drug-free periods characterize the behavior of experienced heroin and cocaine users, and of people in dietary treatment who attempt to restrict the intake of high-fat palatable food. The behavioral and neurochemical events that contribute to these high relapse rates, however, are not well understood. Relapse can be induced in human subjects and laboratory animals by reexposure to the drug (or food) previously used, re-exposure to environmental cues paired with drug (or food) self-administration, and by exposure to environmental stressors. We are using different animal models of relapse to study brain systems and neurotransmitters involved in relapse induced by environmental stressors, conditioned drug (or food) cues and drug (or food) re-exposure in rats with a history of heroin, alcohol, methamphetamine, cocaine or palatable high-fat food self-administration.

Project Start
Project End
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Budget End
Support Year
15
Fiscal Year
2014
Total Cost
Indirect Cost
Name
National Institute on Drug Abuse
Department
Type
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LĂȘ, A D; Funk, Douglas; Coen, Kathleen et al. (2018) Role of ?-Opioid Receptors in the Bed Nucleus of Stria Terminalis in Reinstatement of Alcohol Seeking. Neuropsychopharmacology 43:838-850
Marchant, Nathan J; Campbell, Erin J; Kaganovsky, Konstantin (2018) Punishment of alcohol-reinforced responding in alcohol preferring P rats reveals a bimodal population: Implications for models of compulsive drug seeking. Prog Neuropsychopharmacol Biol Psychiatry 87:68-77
Xue, Yan-Xue; Chen, Ya-Yun; Zhang, Li-Bo et al. (2017) Selective Inhibition of Amygdala Neuronal Ensembles Encoding Nicotine-Associated Memories Inhibits Nicotine Preference and Relapse. Biol Psychiatry 82:781-793
Golden, S A; Aleyasin, H; Heins, R et al. (2017) Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice. Genes Brain Behav 16:44-55
Golden, Sam A; Heins, Conor; Venniro, Marco et al. (2017) Compulsive Addiction-like Aggressive Behavior in Mice. Biol Psychiatry 82:239-248
Pelloux, Yann; K Hoots, Jennifer; Cifani, Carlo et al. (2017) Context-induced relapse to cocaine seeking after punishment-imposed abstinence is associated with activation of cortical and subcortical brain regions. Addict Biol :
Caprioli, Daniele; Venniro, Marco; Zhang, Michelle et al. (2017) Role of Dorsomedial Striatum Neuronal Ensembles in Incubation of Methamphetamine Craving after Voluntary Abstinence. J Neurosci 37:1014-1027
Adhikary, Sweta; Caprioli, Daniele; Venniro, Marco et al. (2017) Incubation of extinction responding and cue-induced reinstatement, but not context- or drug priming-induced reinstatement, after withdrawal from methamphetamine. Addict Biol 22:977-990
Solis Jr, Ernesto; Cameron-Burr, Keaton T; Shaham, Yavin et al. (2017) Intravenous Heroin Induces Rapid Brain Hypoxia and Hyperglycemia that Precede Brain Metabolic Response. eNeuro 4:
Sharpe, Melissa J; Marchant, Nathan J; Whitaker, Leslie R et al. (2017) Lateral Hypothalamic GABAergic Neurons Encode Reward Predictions that Are Relayed to the Ventral Tegmental Area to Regulate Learning. Curr Biol 27:2089-2100.e5

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