Data collected so far demonstrate that vHipp fibers are uniquely concentrated in the medial NAc shell. In this region vHipp input is predominant and selectively strengthened following cocaine injections. Bidirectional optogenetic manipulations in vivo have shown that vHipp input to the NAc drives cocaine-induced locomotion. The most notable finding thus far is that optical stimulations designed to offset the differential potency of each afferent pathway have proved that each excitatory input can reinforce instrumental behavior. These results suggest that the specific excitatory pathway activated is not as important as how much glutamate is released into the NAc, at least in terms of generating motivated behaviors.

Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2013
Total Cost
$690,869
Indirect Cost
Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code
Britt, Jonathan P; Bonci, Antonello (2013) Optogenetic interrogations of the neural circuits underlying addiction. Curr Opin Neurobiol 23:539-45