Functional imaging techniques are being used to characterize brain activation patterns in normal subjects and individuals with neurological disorders affecting human communication. Brain activation patterns characterized using fMRI, EEG, MEG and other brain mapping techniques are used to characterize phenotypic presentation, pathophysiology and treatment of communication disorders. Structural and functional MRI studies are performed on GE and Siemens 3.0 Tesla instruments. Functional images are acquired using echoplanar imaging and arterial spin-tagging methods. Data are analyzed using MEDx, AFNI, and SPM software and newer covariance techniques developed in the Section. High density EEG studies are conducted using a Neuroscan 64 channel system and analyzed using BESA, Neuroscan and Brain Voyager packages. MEG data are collected on a 275 channel CTF instrument. Our research is aimed in large part at understanding the neural correlates of higher level, natural language use including both comprehension and production. We are particularly interested in spontaneity, communicative intent and interactions of the language system with other cognitive domains when language is used in a social context - at the level of discourse. A series of combined hemodynamic and electrophysiological studies of language use at this level in normal volunteers demonstrated unique task related patterns of brain activity that will serve as a baseline when these paradigms are used to study language recovery in post-stroke aphasia and traumatic brain injury. We are actively following an important and heretofore neglected population of aphasic patients who are "recovered" at lexical and grammatical levels, but show significant and clinically relevant impairments at the discourse level. Functional and structural MRI studies evaluating relationships between discourse level symptoms and lesion location on a voxel-wise basis have been completed in this population. We also study the interactions between natural language and speech motor control in developmental stuttering. Work completed over the past several years has included functional MRI and MEG studies of confrontational naming and syntactic comprehension conducted in aphasic patients that demonstrated unique patterns of activity in perilesional and contralesional cortical regions associated with normal and abnormal language production and comprehension. MEG studies of syntactic comprehension in control subject have demonstrated differential activation associated with comprehension of simple and complex syntactic constructions. These methods will now be applied in clinical studies evaluating recovery of in aphasic patients. We are have collected data and are in the process of analyzing fMRI studies of storytelling, story comprehension. These studies have demonstrated unique patterns of brain activity in during creative production of language. Studies of dyadic conversation (based on simultaneous acquisition of images in two interlocutors) have been completed and are being analyzed and prepared for publication. Additional studies in which fMRI and electrophysiological methods are combined to study language processing in controls and patients with speech-language disorders are underway.

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National Institute on Deafness and Other Communication Disorders
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Chow, Ho Ming; Mar, Raymond A; Xu, Yisheng et al. (2015) Personal experience with narrated events modulates functional connectivity within visual and motor systems during story comprehension. Hum Brain Mapp 36:1494-505
Raza, M Hashim; Domingues, Carlos E F; Webster, Ronald et al. (2015) Mucolipidosis types II and III and non-syndromic stuttering are associated with different variants in the same genes. Eur J Hum Genet :
Stager, Sheila V; Freeman, Frances J; Braun, Allen (2015) Characteristics of Fluency and Speech in Two Families With High Incidences of Stuttering. J Speech Lang Hear Res 58:1440-51
Chu, Ron K O; Braun, Allen R; Meltzer, Jed A (2015) MEG-based detection and localization of perilesional dysfunction in chronic stroke. Neuroimage Clin 8:157-69
Raza, M Hashim; Mattera, Rafael; Morell, Robert et al. (2015) Association between Rare Variants in AP4E1, a Component of Intracellular Trafficking, and Persistent Stuttering. Am J Hum Genet 97:715-25
Liu, Siyuan; Erkkinen, Michael G; Healey, Meghan L et al. (2015) Brain activity and connectivity during poetry composition: Toward a multidimensional model of the creative process. Hum Brain Mapp 36:3351-72
AbdulSabur, Nuria Y; Xu, Yisheng; Liu, Siyuan et al. (2014) Neural correlates and network connectivity underlying narrative production and comprehension: a combined fMRI and PET study. Cortex 57:107-27
Chow, Ho Ming; Mar, Raymond A; Xu, Yisheng et al. (2014) Embodied comprehension of stories: interactions between language regions and modality-specific neural systems. J Cogn Neurosci 26:279-95
Picchioni, Dante; Pixa, Morgan L; Fukunaga, Masaki et al. (2014) Decreased connectivity between the thalamus and the neocortex during human nonrapid eye movement sleep. Sleep 37:387-97
Xu, Yisheng; Tong, Yunxia; Liu, Siyuan et al. (2014) Denoising the speaking brain: toward a robust technique for correcting artifact-contaminated fMRI data under severe motion. Neuroimage 103:33-47

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