We continue to develop mathematical models of human metabolism and have conducted several validation studies using a variety of published data on the metabolic responses to overfeeding, underfeeding, and isocaloric changes in dietary macronutrients. Our models have been deployed as a clinical research tool in collaboration with NIH clinical investigators to help design prospective studies as well as plan and track clinical weight management programs. Our models are being applied to a variety of problems, from calculating the relationship between human weight change and food intake to calculating changes of free-living energy intake using frequent body weight measurements.

Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2011
Total Cost
$341,328
Indirect Cost
City
State
Country
Zip Code
Hall, Kevin D; Guo, Juen (2017) Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition. Gastroenterology 152:1718-1727.e3
Katan, Martijn B; de Ruyter, Janne C; Kuijper, Lothar D J et al. (2016) Impact of Masked Replacement of Sugar-Sweetened with Sugar-Free Beverages on Body Weight Increases with Initial BMI: Secondary Analysis of Data from an 18 Month Double-Blind Trial in Children. PLoS One 11:e0159771
Polidori, David; Sanghvi, Arjun; Seeley, Randy J et al. (2016) How Strongly Does Appetite Counter Weight Loss? Quantification of the Feedback Control of Human Energy Intake. Obesity (Silver Spring) 24:2289-2295
MacLeod, Erin L; Hall, Kevin D; McGuire, Peter J (2016) Computational modeling to predict nitrogen balance during acute metabolic decompensation in patients with urea cycle disorders. J Inherit Metab Dis 39:17-24
Freedhoff, Yoni; Hall, Kevin D (2016) Weight loss diet studies: we need help not hype. Lancet 388:849-51
Lobstein, Tim; Jackson-Leach, Rachel; Moodie, Marjory L et al. (2015) Child and adolescent obesity: part of a bigger picture. Lancet 385:2510-20
Ferrannini, Giulia; Hach, Thomas; Crowe, Susanne et al. (2015) Energy Balance After Sodium-Glucose Cotransporter 2 Inhibition. Diabetes Care 38:1730-5
Dietz, William H; Baur, Louise A; Hall, Kevin et al. (2015) Management of obesity: improvement of health-care training and systems for prevention and care. Lancet 385:2521-33
MacLean, Paul S; Wing, Rena R; Davidson, Terry et al. (2015) NIH working group report: Innovative research to improve maintenance of weight loss. Obesity (Silver Spring) 23:7-15
Hall, Kevin D; Bemis, Thomas; Brychta, Robert et al. (2015) Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity. Cell Metab 22:427-36

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