We continue to develop mathematical models of human metabolism and have conducted several validation studies using a variety of published data on the metabolic responses to overfeeding, underfeeding, and isocaloric changes in dietary macronutrients. Our models have been deployed as an online body weight simulator at http://bwsimulator.niddk.nih.gov to help design prospective studies as well as plan and track clinical weight management programs. Our models are being applied to a variety of problems, from calculating the relationship between human weight change and food intake to calculating changes of free-living energy intake using frequent body weight measurements. We have also used our models to help address policy issues such as the likely effect of soda taxes on US obesity prevalence.

Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2013
Total Cost
$338,364
Indirect Cost
City
State
Country
Zip Code
Chow, Carson C; Hall, Kevin D (2014) Short and long-term energy intake patterns and their implications for human body weight regulation. Physiol Behav 134:60-5
Hall, Kevin D (2014) Estimating human energy intake using mathematical models. Am J Clin Nutr 100:744-5
Hall, K D; Chow, C C (2013) Why is the 3500 kcal per pound weight loss rule wrong? Int J Obes (Lond) 37:1614
Lieffers, Jessica R; Mourtzakis, Marina; Hall, Kevin D et al. (2009) A viscerally driven cachexia syndrome in patients with advanced colorectal cancer: contributions of organ and tumor mass to whole-body energy demands. Am J Clin Nutr 89:1173-9
Hall, Kevin D; Baracos, Vickie E (2008) Computational modeling of cancer cachexia. Curr Opin Clin Nutr Metab Care 11:214-21
Hall, Kevin D; Jordan, Peter N (2008) Modeling weight-loss maintenance to help prevent body weight regain. Am J Clin Nutr 88:1495-503