Abstract

Natural products - small molecules biosynthesized primarily by microorganisms, fungi and invertebrates - are engendered with diverse chemical structures that give rise to a broad range of biological activities and account for the majority of currently used therapeutics. With an emphasis on marine invertebrates, we have identified several classes of novel marine natural products that potently inhibit tumor cell growth in vitro, and HIV-1 infection. By employing distinct but complementary HIV-1 assays, we demonstrated that mirabamides, glycosylated and halogenated depsipeptides, inhibit HIV-1 infection at the early stage of entry, and the activity profiles for the suite of depsipeptides provided new structure activity relationships for this class of compounds.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADK031135-04
Application #
8148731
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2010
Total Cost
$806,033
Indirect Cost

  Institution

Name
National Institute of Diabetes and Digestive and Kidney Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Liu, Hong-Bing; Lauro, Gianluigi; O'Connor, Robert D et al. (2017) Tulongicin, an Antibacterial Tri-Indole Alkaloid from a Deep-Water Topsentia sp. Sponge. J Nat Prod 80:2556-2560
Davison, Jack R; Lohith, Katheryn M; Wang, Xiaoning et al. (2017) A New Natural Product Analog of Blasticidin S Reveals Cellular Uptake Facilitated by the NorA Multidrug Transporter. Antimicrob Agents Chemother 61:
Shahzad-Ul-Hussan, Syed; Sastry, Mallika; Lemmin, Thomas et al. (2017) Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins. Chembiochem 18:764-771
Shi, Jingmin; Xie, Cen; Liu, Hongbing et al. (2016) Metabolism and Bioactivation of Fluorochloridone, a Novel Selective Herbicide, in Vivo and in Vitro. Environ Sci Technol 50:9652-60
Melander, Roberta J; Liu, Hong-Bing; Stephens, Matthew D et al. (2016) Marine sponge alkaloids as a source of anti-bacterial adjuvants. Bioorg Med Chem Lett 26:5863-5866
Liu, Hongbing; Lohith, Katheryn; Rosario, Margaret et al. (2016) Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity. J Nat Prod 79:1872-6
Acharya, Priyamvada; Lusvarghi, Sabrina; Bewley, Carole A et al. (2015) HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth. Expert Opin Ther Targets 19:765-83
Sastry, Mallika; Bewley, Carole A; Kwong, Peter D (2015) Effective isotope labeling of proteins in a mammalian expression system. Methods Enzymol 565:289-307
Lusvarghi, Sabrina; Ghirlando, Rodolfo; Wong, Chi-Huey et al. (2015) Glycopeptide mimetics recapitulate high-mannose-type oligosaccharide binding and function. Angew Chem Int Ed Engl 54:5603-8
Vassilopoulos, Athanassios; Xiao, Cuiying; Chisholm, Cristine et al. (2014) Synergistic therapeutic effect of cisplatin and phosphatidylinositol 3-kinase (PI3K) inhibitors in cancer growth and metastasis of Brca1 mutant tumors. J Biol Chem 289:24202-14

Showing the most recent 10 out of 29 publications