Since the clinical trial began in 2002, 5,145 volunteers with type 2 diabetes who were 45-76 years of age and overweight or obese (body mass index >25 kg/m2) have been recruited and enrolled in either the intensive lifestyle intervention (ILI) program or the diabetes support and education (DSE) program. The Diabetes Epidemiology and Clinical Research Section clinics enrolled 244 of these participants. The study has reported success in achieving and maintaining weight loss in the ILI group, while there was little weight loss on average in the DSE group. During the first four years after enrollment, the average weight losses were 6.2% in the ILI group and 0.9% in the DSE group. This successful weight loss means that it will be possible, at the end of the study, to determine if weight loss has long-term health benefits in adults with type 2 diabetes. The study continues these two interventions and outcome assessments so that the primary study questions can be answered in 2015. We are, therefore, making outstanding progress in delivering the interventions and following participants in order to answer the primary health outcomes questions described in the protocol.

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Belalcazar, L Maria; Papandonatos, George D; Erar, Bahar et al. (2016) Lifestyle Intervention for Weight Loss and Cardiometabolic Changes in the Setting of Glucokinase Regulatory Protein Inhibition: Glucokinase Regulatory Protein-Leu446Pro Variant in Look AHEAD. Circ Cardiovasc Genet 9:71-8
Zhang, Ping; Hire, Don; Espeland, Mark A et al. (2016) Impact of intensive lifestyle intervention on preference-based quality of life in type 2 diabetes: Results from the Look AHEAD trial. Obesity (Silver Spring) 24:856-64
Papandonatos, George D; Pan, Qing; Pajewski, Nicholas M et al. (2015) Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials. Diabetes 64:4312-21
Neiberg, Rebecca H; Rejeski, Jared J; Applegate, William B et al. (2015) Self-Reported Gastrointestinal Symptoms in Type 2 Diabetes Improve With an Intensive Lifestyle Intervention: Results From the Action for Health in Diabetes (Look AHEAD) Clinical Trial. Clin Diabetes 33:181-8
Espeland, Mark A; Probstfield, Jeffery; Hire, Donald et al. (2015) Systolic Blood Pressure Control Among Individuals With Type 2 Diabetes: A Comparative Effectiveness Analysis of Three Interventions. Am J Hypertens 28:995-1009
Espeland, Mark A; Glick, Henry A; Bertoni, Alain et al. (2014) Impact of an intensive lifestyle intervention on use and cost of medical services among overweight and obese adults with type 2 diabetes: the action for health in diabetes. Diabetes Care 37:2548-56
Knowler, William C; Bahnson, Judy L; Bantle, John P et al. (2014) Diabetic kidneys do deserve a lifestyle change. Lancet Diabetes Endocrinol 2:776
Rubin, Richard R; Wadden, Thomas A; Bahnson, Judy L et al. (2014) Impact of intensive lifestyle intervention on depression and health-related quality of life in type 2 diabetes: the Look AHEAD Trial. Diabetes Care 37:1544-53
Espeland, Mark A; Lewis, Cora E; Bahnson, Judy et al. (2014) Impact of weight loss on ankle-brachial index and interartery blood pressures. Obesity (Silver Spring) 22:1032-41
McCaffery, Jeanne M; Papandonatos, George D; Huggins, Gordon S et al. (2013) Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial. Hum Hered 75:160-74

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