We are contributing to NTP technical reports of rodent bioassays on cobalt, vinylidene chloride (an intermediate in polymer production), tetrabromobisphenol-A (a flame retardant), glycidamide, green tea extract, bromodichloroacetic acid (a water disinfection byproduct) that will be reviewed by the NTP Board of Scientific Counselors in the fall and early next spring. We also participated in study design committees for over 12 chemicals that will be tested by the NTP. We published papers in the scientific literature on chemicals that were recently tested by the NTP: hexavalent chromium and Gingko biloba. The NTP's extensive testing program provides opportunities to investigate patterns across studies. We contributed to a multi-study evaluation of rat pancreatic islet cell tumors which showed that protein expression in these tumors was similar to that found in humans. The immunohistochemical characterization of these tumors also provided indications of possible pathways for carcinogenesis in islet cells. We continued to provide advice on statistical methods for evaluating alternative methods for NTP's toxicity and carcinogenicity testing. These include: 1) providing advice about the analysis of high throughput data from cell-based assays of chemicals selected by the NTP, that were generated by the NIH Chemical Genomics Center, 2) providing advice about applying the up-and-down procedure to dermal toxicity testing, and 3) providing advice about how to combine batteries of in vitro test results to predict in vivo results.

Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
2013
Total Cost
$111,132
Indirect Cost
City
State
Country
Zip Code
Ryan, Kristen R; Cesta, Mark F; Herbert, Ronald et al. (2016) Comparative pulmonary toxicity of inhaled metalworking fluids in rats and mice. Toxicol Ind Health :
Rider, Cynthia V; Chan, Po; Herbert, Ron A et al. (2016) Dermal Exposure to Cumene Hydroperoxide: Assessing Its Toxic Relevance and Oxidant Potential. Toxicol Pathol 44:749-62
Frawley, Rachel P; Smith, Matthew J; White Jr, Kimber L et al. (2016) Immunotoxic effects of sodium tungstate dihydrate on female B6C3F1/N mice when administered in drinking water. J Immunotoxicol 13:666-75
Sanders, J Michael; Coulter, Sherry J; Knudsen, Gabriel A et al. (2016) Disruption of estrogen homeostasis as a mechanism for uterine toxicity in Wistar Han rats treated with tetrabromobisphenol A. Toxicol Appl Pharmacol 298:31-9
Willson, C J; Flake, G P; Sills, R C et al. (2016) Immunohistochemical Expression of Cyclin D1, Cytokeratin 20, and Uroplakin III in Proliferative Urinary Bladder Lesions Induced by o-Nitroanisole in Fischer 344/N Rats. Vet Pathol 53:682-90
Dunnick, J K; Sanders, J M; Kissling, G E et al. (2015) Environmental chemical exposure may contribute to uterine cancer development: studies with tetrabromobisphenol A. Toxicol Pathol 43:464-73
Hong, Hue-Hua L; Hoenerhoff, Mark J; Ton, Thai-Vu et al. (2015) Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal. Toxicol Pathol 43:872-82
Surh, Inok; Rao, Deepa B; Cesta, Mark F et al. (2014) Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice. Food Chem Toxicol 66:254-61
Rider, Cynthia V; Nyska, Abraham; Cora, Michelle C et al. (2014) Toxicity and carcinogenicity studies of Ginkgo biloba extract in rat and mouse: liver, thyroid, and nose are targets. Toxicol Pathol 42:830-43
Waalkes, Michael P; Qu, Wei; Tokar, Erik J et al. (2014) Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses. Arch Toxicol 88:1619-29

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