We are contributing to NTP technical reports of rodent bioassays on cobalt, vinylidene chloride (an intermediate in polymer production), tetrabromobisphenol-A (a flame retardant), glycidamide, green tea extract, bromodichloroacetic acid (a water disinfection byproduct) that will be reviewed by the NTP Board of Scientific Counselors in the fall and early next spring. We also participated in study design committees for over 12 chemicals that will be tested by the NTP. We published papers in the scientific literature on chemicals that were recently tested by the NTP: hexavalent chromium and Gingko biloba. The NTP's extensive testing program provides opportunities to investigate patterns across studies. We contributed to a multi-study evaluation of rat pancreatic islet cell tumors which showed that protein expression in these tumors was similar to that found in humans. The immunohistochemical characterization of these tumors also provided indications of possible pathways for carcinogenesis in islet cells. We continued to provide advice on statistical methods for evaluating alternative methods for NTP's toxicity and carcinogenicity testing. These include: 1) providing advice about the analysis of high throughput data from cell-based assays of chemicals selected by the NTP, that were generated by the NIH Chemical Genomics Center, 2) providing advice about applying the up-and-down procedure to dermal toxicity testing, and 3) providing advice about how to combine batteries of in vitro test results to predict in vivo results.

Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
2013
Total Cost
$111,132
Indirect Cost
City
State
Country
Zip Code
Rider, Cynthia V; Nyska, Abraham; Cora, Michelle C et al. (2014) Toxicity and carcinogenicity studies of Ginkgo biloba extract in rat and mouse: liver, thyroid, and nose are targets. Toxicol Pathol 42:830-43
Waalkes, Michael P; Qu, Wei; Tokar, Erik J et al. (2014) Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses. Arch Toxicol 88:1619-29
Surh, Inok; Rao, Deepa B; Cesta, Mark F et al. (2014) Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice. Food Chem Toxicol 66:254-61
Witt, Kristine L; Stout, Matthew D; Herbert, Ronald A et al. (2013) Mechanistic insights from the NTP studies of chromium. Toxicol Pathol 41:326-42
Boyd, Windy A; Smith, Marjolein V; Kissling, Grace E et al. (2010) Medium- and high-throughput screening of neurotoxicants using C. elegans. Neurotoxicol Teratol 32:68-73
Stout, Matthew D; Herbert, Ronald A; Kissling, Grace E et al. (2009) Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure. Environ Health Perspect 117:716-22
Sanders, J M; Bucher, J R; Peckham, J C et al. (2009) Carcinogenesis studies of cresols in rats and mice. Toxicology 257:33-9
Stout, M D; Nyska, A; Collins, B J et al. (2009) Chronic toxicity and carcinogenicity studies of chromium picolinate monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2 years. Food Chem Toxicol 47:729-33
Stout, Matthew D; Herbert, Ronald A; Kissling, Grace E et al. (2008) Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure. Toxicology 244:209-19
Chan, P C; Hill, G D; Hills, G D et al. (2008) Toxicity and carcinogenicity studies of 4-methylimidazole in F344/N rats and B6C3F1 mice. Arch Toxicol 82:45-53

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