Abstract

Organochlorines such as DDT, its metabolite DDE, and polychlorinated biphenyls (PCBs) are persistent organic pollutants that may be toxic at levels encountered by the general population, through exposure in the food chain. Each organochlorine has one or more types of biologic activity, and corresponding potential mechanisms of action. Last year's progress I collaborated with investigators who had studied pregnancies among a population with relatively high exposure to DDT in China. We published a study on the relation of DDT and its metabolite DDE to reproductive outcomes. Our results provide suggestive evidence that B12 and folate sufficiency may help protect against adverse reproductive effects of DDT exposure.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAES049016-20
Application #
9143432
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Savitz, David A; Klebanoff, Mark A; Wellenius, Gregory A et al. (2014) Persistent organochlorines and hypertensive disorders of pregnancy. Environ Res 132:1-5
Lehmann, Geniece M; Verner, Marc-André; Luukinen, Bryan et al. (2014) Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk. Crit Rev Toxicol 44:600-17
Ouyang, Fengxiu; Longnecker, Matthew P; Venners, Scott A et al. (2014) Preconception serum 1,1,1-trichloro-2,2,bis(p-chlorophenyl)ethane and B-vitamin status: independent and joint effects on women's reproductive outcomes. Am J Clin Nutr 100:1470-8
Verner, Marc-André; McDougall, Robin; Glynn, Anders et al. (2013) Is the relationship between prenatal exposure to PCB-153 and decreased birth weight attributable to pharmacokinetics? Environ Health Perspect 121:1219-24
Li, Daniel; Longnecker, Matthew P; Dunson, David B (2013) Lipid adjustment for chemical exposures: accounting for concomitant variables. Epidemiology 24:921-8
Cupul-Uicab, Lea A; Klebanoff, Mark A; Brock, John W et al. (2013) Prenatal exposure to persistent organochlorines and childhood obesity in the US collaborative perinatal project. Environ Health Perspect 121:1103-9
Jusko, Todd A; Sonneborn, Dean; Palkovicova, Lubica et al. (2012) Pre- and postnatal polychlorinated biphenyl concentrations and longitudinal measures of thymus volume in infants. Environ Health Perspect 120:595-600
Jusko, Todd A; Klebanoff, Mark A; Brock, John W et al. (2012) In-utero exposure to dichlorodiphenyltrichloroethane and cognitive development among infants and school-aged children. Epidemiology 23:689-98
Trabert, Britton; Longnecker, Matthew P; Brock, John W et al. (2012) Maternal pregnancy levels of trans-nonachlor and oxychlordane and prevalence of cryptorchidism and hypospadias in boys. Environ Health Perspect 120:478-82
Trnovec, Tomas; Dedik, Ladislav; Jusko, Todd A et al. (2011) Assessment of exposure to PCB 153 from breast feeding and normal food intake in individual children using a system approach model. Chemosphere 85:1687-93

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