Manuscripts that were published during this year are listed below and there are several that are either in preparation or submitted for publcaition. Some examples of collaborative research are given below: 1. Kadekar et al. (2012): Differences in cancer incidences between gender are often attributed to differences in exposures or influences of sex hormones. However, there are not many studies on gender differences in susceptibility to chemical carcinogens. Using the rich NTP database, in this paper we investigated sex differences in tumor responses in rats to various chemical carcinogens. Of the 278 carcinogenic chemicals in the NTP database, 201 (72%) exhibited gender differences (significant at 0.05 level of significance) in at least one non-reproductive organ. Of the 201 such cehmicals, 130 chemicals induced gender-specific tumors in male rats and 59 in female rats. 68 chemicals induced tumors in males but not in females and conversely, 19 chemicals induced tumors in females but not males. Male-specific tumors included pancreatic tumor and skin tumor, and female-specific tumors included lung tumors. 2. Joubert et a;. (2012): An object of this research is to examine the epigenetic modifications, such as DNA methylation, caused by in utero exposures to maternal smoking. Maternal smoking is a major risk factor for multiple adverse health outcomes in children but the underlying mechanisms are not well understood. In this project we collected cord blood samples from newborns and investigated epigenome-wide methylation in relation to maternal smoking during pregnancy. We identified a several genes with methylation changes present at birth in children of mothers who smoked during pregnancy. This study is first of its kind to investigate the effect of maternal smoking during pregnancy on methylation across the genome using the 450K platform.

Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2012
Total Cost
$129,562
Indirect Cost
City
State
Country
Zip Code
Lowe, Julie M; Nguyen, Thuy-Ai; Grimm, Sara A et al. (2017) The novel p53 target TNFAIP8 variant 2 is increased in cancer and offsets p53-dependent tumor suppression. Cell Death Differ 24:181-191
Hill-Burns, Erin M; Debelius, Justine W; Morton, James T et al. (2017) Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome. Mov Disord 32:739-749
Reese, Sarah E; Zhao, Shanshan; Wu, Michael C et al. (2017) DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy. Environ Health Perspect 125:760-766
Joubert, Bonnie R; den Dekker, Herman T; Felix, Janine F et al. (2016) Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns. Nat Commun 7:10577
Reber, Stefan O; Siebler, Philip H; Donner, Nina C et al. (2016) Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice. Proc Natl Acad Sci U S A 113:E3130-9
Hayes, Schantel A; Pandiri, Arun R; Ton, Thai-vu T et al. (2016) Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation. Toxicol Pathol 44:71-87
Yamashita, Haruhiro; Hoenerhoff, Mark J; Peddada, Shyamal D et al. (2016) Chemical Exacerbation of Light-induced Retinal Degeneration in F344/N Rats in National Toxicology Program Rodent Bioassays. Toxicol Pathol 44:892-903
Harvey, J B; Hong, H-H L; Bhusari, S et al. (2015) F344/NTac Rats Chronically Exposed to Bromodichloroacetic Acid Develop Mammary Adenocarcinomas With Mixed Luminal/Basal Phenotype and Tgf? Dysregulation. Vet Pathol :
Kadiiska, Maria B; Peddada, Shyamal; Herbert, Ronald A et al. (2015) Biomarkers of oxidative stress study VI. Endogenous plasma antioxidants fail as useful biomarkers of endotoxin-induced oxidative stress. Free Radic Biol Med 81:100-6
Blackshear, Pamela E; Pandiri, Arun R; Nagai, Hiroaki et al. (2015) Gene expression of mesothelioma in vinylidene chloride-exposed F344/N rats reveal immune dysfunction, tissue damage, and inflammation pathways. Toxicol Pathol 43:171-85

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