Statistical collaboration in environmental health research

Kissling, Grace E.

Abstract

We provide biostatistics expertise for a number of NIEHS and NTP researchers, as well as researchers at universities and other government agencies who are conducting research related to the mission of the NIEHS. In these collaborations, we provide advice about study design, analyze data, interpret statistical results, and coauthor papers for publication. We have a long-standing collaboration with Dr. Dixon's laboratory, which is researching leiomyomas (uterine fibroids). In the studies published this year, genomic characteristics of the tumor tissue, signaling pathways and effects of cadmium exposure on leiomyoma cell cultures were investigated. We analyzed data in a study of reproductive endpoints and metabolic parameters of mice exposed to arsenic and showed that arsenic had adverse effects at doses lower than previously demonstrated. In collaboration with the NTP, we analyzed data from two human studies of bisphenol A (BPA) and related compounds. In one study, we documented pharmacokinetics properties of BPA orally consumed by volunteers. In a second study, we examined blood and urine concentrations of BPA and two related compounds in cashiers who handled thermal receipt paper, which contains BPA or one of two substitutes for BPA. In several surveys of U.S. and international research institutions, we characterized several aspects of research ethics policies including: authorship, conflict of interest, research misconduct and publication retraction.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIAES103106-05
• Application #: 9352157
• Support Year: 5
• Fiscal Year: 2016

Institution

• Name: U.S. National Inst of Environ Hlth Scis

Publications

Resnik, David B; Konecny, Brandon; Kissling, Grace E (2017) Conflict of Interest and Funding Disclosure Policies of Environmental, Occupational, and Public Health Journals. J Occup Environ Med 59:28-33

Ungewitter, Erica; Rotgers, Emmi; Bantukul, Tanika et al. (2017) From the Cover: Teratogenic Effects of in Utero Exposure to Di-(2-Ethylhexyl)-Phthalate (DEHP) in B6:129S4 Mice. Toxicol Sci 157:8-19

Ogburn, Ryenne N; Randall, Thomas A; Xu, Yingrong et al. (2017) Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins? J Allergy Clin Immunol 139:1030-1032.e1

Wyss, Annah B; Jones, Anna Ciesielski; Bølling, Anette K et al. (2016) Particulate Matter 2.5 Exposure and Self-Reported Use of Wood Stoves and Other Indoor Combustion Sources in Urban Nonsmoking Homes in Norway. PLoS One 11:e0166440

Resnik, David B; Ariansen, J L; Jamal, Jaweria et al. (2016) Institutional Conflict of Interest Policies at U.S. Academic Research Institutions. Acad Med 91:242-6

Mozzachio, Kristie; Moore, Alicia B; Kissling, Grace E et al. (2016) Immunoexpression of Steroid Hormone Receptors and Proliferation Markers in Uterine Leiomyoma and Normal Myometrial Tissues from the Miniature Pig, Sus scrofa. Toxicol Pathol 44:450-7

Rodriguez, Karina F; Ungewitter, Erica K; Crespo-Mejias, Yasmin et al. (2016) Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice. Environ Health Perspect 124:336-43

Castro, Lysandra; Gao, Xioahua; Moore, Alicia B et al. (2016) A High Concentration of Genistein Induces Cell Death in Human Uterine Leiomyoma Cells by Autophagy. Expert Opin Environ Biol 5:

Resnik, David B; Tyler, Ana M; Black, Jennifer R et al. (2016) Authorship policies of scientific journals. J Med Ethics 42:199-202

Blankenship-Paris, Terry L; Dutton, John W; Goulding, David R et al. (2016) Evaluation of buprenorphine hydrochloride Pluronic(®) gel formulation in male C57BL/6NCrl mice. Lab Anim (NY) 45:370-9