In the AGES cohort we are estimating the prevalence and risk factors of eye disease as well investigating possible functional correlates in persons exhibiting clinical signs of disease in other organ systems, including the brain. For example, AGES data confirms that retinopathy lesions are found in older people who do not have diabetes;lesions in persons without diabetes constitute the majority (78%) of retinopathy cases. Usually the retinal lesions are mild. Kidney dysfunction is also likely to be present in affected individuals. AGES is a member of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. As such, it is involved in genetic meta-analysis for discovery or replication of genetic variants of disease. AGES has partnered with international collaborators and published several of its findings in the past year. For more information on the AGES study (design, progress and findings), see Refer to project bibliography on the study website for published papers and papers in press. See also ZIAAG007380 and ZIAG006000(Dr. Harris).

National Institute of Health (NIH)
National Eye Institute (NEI)
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U.S. National Eye Institute
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Fisher, Diana E; Jonasson, Fridbert; Eiriksdottir, Gudny et al. (2015) Age-related macular degeneration and mortality in community-dwelling elders: the age, gene/environment susceptibility Reykjavik study. Ophthalmology 122:382-90
Fisher, Diana; Li, Chuan-Ming; Chiu, May S et al. (2014) Impairments in hearing and vision impact on mortality in older people: the AGES-Reykjavik Study. Age Ageing 43:69-76
Jonasson, Fridbert; Fisher, Diana E; Eiriksdottir, Gudny et al. (2014) Five-year incidence, progression, and risk factors for age-related macular degeneration: the age, gene/environment susceptibility study. Ophthalmology 121:1766-72
Semba, Richard D; Cotch, Mary Frances; Gudnason, Vilmundur et al. (2014) Serum carboxymethyllysine, an advanced glycation end product, and age-related macular degeneration: the Age, Gene/Environment Susceptibility-Reykjavik Study. JAMA Ophthalmol 132:464-70
Steingrimsdottir, Laufey; Halldorsson, Thorhallur I; Siggeirsdottir, Kristin et al. (2014) Hip fractures and bone mineral density in the elderly--importance of serum 25-hydroxyvitamin D. PLoS One 9:e91122
Vidarsdottir, Halldora; Fang, Fang; Chang, Milan et al. (2014) Spousal loss and cognitive function in later life: a 25-year follow-up in the AGES-Reykjavik study. Am J Epidemiol 179:674-83
van Ballegooijen, A J; Visser, M; Cotch, M F et al. (2013) Serum vitamin D and parathyroid hormone in relation to cardiac structure and function: the ICELAND-MI substudy of AGES-Reykjavik. J Clin Endocrinol Metab 98:2544-52
Sim, Xueling; Jensen, Richard A; Ikram, M Kamran et al. (2013) Genetic loci for retinal arteriolar microcirculation. PLoS One 8:e65804
Jensen, Richard A; Sim, Xueling; Li, Xiaohui et al. (2013) Genome-wide association study of retinopathy in individuals without diabetes. PLoS One 8:e54232
Holliday, Elizabeth G; Smith, Albert V; Cornes, Belinda K et al. (2013) Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. PLoS One 8:e53830

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