In the AGES cohort we are estimating the prevalence and risk factors of eye disease as well investigating possible functional correlates in persons exhibiting clinical signs of disease in other organ systems, including the brain. For example, AGES data confirms that retinopathy lesions are found in older people who do not have diabetes;lesions in persons without diabetes constitute the majority (78%) of retinopathy cases. Usually the retinal lesions are mild. Kidney dysfunction is also likely to be present in affected individuals. AGES is a member of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. As such, it is involved in genetic meta-analysis for discovery or replication of genetic variants of disease. AGES has partnered with international collaborators and published several of its findings in the past year. For more information on the AGES study (design, progress and findings), see www.hjarta.is/english/ages. Refer to project bibliography on the study website for published papers and papers in press. See also ZIAAG007380 and ZIAG006000(Dr. Harris).

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAEY000401-12
Application #
8737627
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2013
Total Cost
$371,135
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
Zip Code
Jensen, Richard A; Sim, Xueling; Smith, Albert Vernon et al. (2016) Novel Genetic Loci Associated With Retinal Microvascular Diameter. Circ Cardiovasc Genet 9:45-54
Cashman, Kevin D; Dowling, Kirsten G; Škrabáková, Zuzana et al. (2016) Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 103:1033-44
Fan, Qiao; Verhoeven, Virginie J M; Wojciechowski, Robert et al. (2016) Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. Nat Commun 7:11008
Tryggvason, Geir; Jonasson, Fridbert; Cotch, Mary Frances et al. (2016) Hearing in older adults with exfoliation syndrome/exfoliation glaucoma or primary open-angle glaucoma. Acta Ophthalmol 94:140-6
Fisher, Diana E; Jonasson, Fridbert; Klein, Ronald et al. (2016) Mortality in Older Persons with Retinopathy and Concomitant Health Conditions: The Age, Gene/Environment Susceptibility-Reykjavik Study. Ophthalmology 123:1570-80
Fisher, Diana E; Jonasson, Fridbert; Eiriksdottir, Gudny et al. (2015) Age-related macular degeneration and mortality in community-dwelling elders: the age, gene/environment susceptibility Reykjavik study. Ophthalmology 122:382-90
Fisher, Diana E; Li, Chuan-Ming; Hoffman, Howard J et al. (2015) Sex-specific predictors of hearing-aid use in older persons: The age, gene/environment susceptibility - Reykjavik study. Int J Audiol 54:634-41
Imai, Cindy M; Halldorsson, Thorhallur I; Eiriksdottir, Gudny et al. (2015) Depression and serum 25-hydroxyvitamin D in older adults living at northern latitudes - AGES-Reykjavik Study. J Nutr Sci 4:e37
Reinders, Ilse; Murphy, Rachel A; Song, Xiaoling et al. (2015) Higher Plasma Phospholipid n-3 PUFAs, but Lower n-6 PUFAs, Are Associated with Lower Pulse Wave Velocity among Older Adults. J Nutr 145:2317-24
Reinders, I; Murphy, R A; Song, X et al. (2015) Polyunsaturated fatty acids in relation to incident mobility disability and decline in gait speed; the Age, Gene/Environment Susceptibility-Reykjavik Study. Eur J Clin Nutr 69:489-93

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