The MESA study is on-going. MESA study visit five began in April 2010 and was completed in early 2012. Participants are currently being followed for health events. Analyses of various ocular phenotypes, including retinal microvascular disease, have resulted in multiple published manuscripts with more under preparation. Genotype and ocular phenotype data began to be released on dbGaP in August 2010. Genetic analyses under the auspices of MESA SHARe, CHARGE, and the BioProject are on-going. MESA has numerous ancillary studies, including a lung component (funded by NHLBI) and an air pollution component (funded by the EPA), allowing all investigators to leverage modest resources for maximal scientific advantage. Discussions to integrate and analyze data across various study components have resulted in several multi-disciplinary collaborations producing numerous peer-reviewed scientific publications, many of which are novel and would likely have been considered too high-risk to have ever received funding on their own. More information about the MESA Study and its ancillary studies, including a full list of participating investigators and institutions and a complete, up-to-date list of publications, can be found at www.mesa-nhlbi.org. For information on how to access MESA data, refer to dbGaP (www.ncbi.nlm.nih.gov/gap).

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAEY000403-13
Application #
8938312
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
2014
Total Cost
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
Zip Code
Fernandez, Antonio B; Ballard, Kevin D; Wong, Tien Y et al. (2018) Age-related macular degeneration and progression of coronary artery calcium: The Multi-Ethnic Study of Atherosclerosis. PLoS One 13:e0201000
Sobrin, Lucia; Chong, Yong He; Fan, Qiao et al. (2017) Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. Diabetes 66:3130-3141
Xie, Jing; Ikram, M Kamran; Cotch, Mary Frances et al. (2017) Association of Diabetic Macular Edema and Proliferative Diabetic Retinopathy With Cardiovascular Disease: A Systematic Review and Meta-analysis. JAMA Ophthalmol 135:586-593
Telomeres Mendelian Randomization Collaboration; Haycock, Philip C; Burgess, Stephen et al. (2017) Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol 3:636-651
Cotch, Mary Frances (2016) Public Health Surveillance-The Integral Role of Community-Based Studies. JAMA Ophthalmol :
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Chew, Merwyn; Xie, Jing; Klein, Ronald et al. (2016) Sleep apnea and retinal signs in cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Sleep Breath 20:15-23
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Fisher, Diana E; Klein, Barbara E K; Wong, Tien Y et al. (2016) Incidence of Age-Related Macular Degeneration in a Multi-Ethnic United States Population: The Multi-Ethnic Study of Atherosclerosis. Ophthalmology 123:1297-308
Lin, Gen-Min; Redline, Susan; Klein, Ronald et al. (2016) Sex-Specific Association of Obstructive Sleep Apnea With Retinal Microvascular Signs: The Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc 5:

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