Enrollment is complete with 5 participants. One participant developed a cataract in the study eye after exiting the study and this may be related to the investigational eye drop (the IRB and FDA were notified). His vision returned to baseline after cataract extraction and the lens was sent for pathology. Three of the five participants developed mild conjunctival erythema while on the eye drop that resolved without sequelae with eye drop discontinuation. No systemic complications have been noted to date. We are continuing to follow these participants. The other participants have had no lens changes to date.

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National Eye Institute (NEI)
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Dalal, Monica; Jacobs-El, Naima; Nicholson, Benjamin et al. (2013) Subconjunctival Palomid 529 in the treatment of neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 251:2705-9
Nicholson, Benjamin; Noble, Jason; Forooghian, Farzin et al. (2013) Central serous chorioretinopathy: update on pathophysiology and treatment. Surv Ophthalmol 58:103-26
Ardeljan, Daniel; Meyerle, Catherine B; Agron, Elvira et al. (2013) Influence of TIMP3/SYN3 polymorphisms on the phenotypic presentation of age-related macular degeneration. Eur J Hum Genet :
Wang, Vinson M; Rosen, Richard B; Meyerle, Catherine B et al. (2012) Suggestive association between PLA2G12A single nucleotide polymorphism rs2285714 and response to anti-vascular endothelial growth factor therapy in patients with exudative age-related macular degeneration. Mol Vis 18:2578-85
Cukras, Catherine A; Petrou, Philip; Chew, Emily Y et al. (2012) Oral minocycline for the treatment of diabetic macular edema (DME): results of a phase I/II clinical study. Invest Ophthalmol Vis Sci 53:3865-74
Toy, Brian C; Koo, Euna; Cukras, Catherine et al. (2012) Treatment of nonneovascular idiopathic macular telangiectasia type 2 with intravitreal ranibizumab: results of a phase II clinical trial. Retina 32:996-1006
Wei, Lai; Liu, Baoying; Tuo, Jingsheng et al. (2012) Hypomethylation of the IL17RC promoter associates with age-related macular degeneration. Cell Rep 2:1151-8
Liu, Melissa M; Agrón, Elvira; Chew, Emily et al. (2011) Copy number variations in candidate genes in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 52:3129-35
Forooghian, Farzin; Meleth, Annal D; Cukras, Catherine et al. (2011) Finasteride for chronic central serous chorioretinopathy. Retina 31:766-71
Krishnadev, Nupura; Forooghian, Farzin; Cukras, Catherine et al. (2011) Subconjunctival sirolimus in the treatment of diabetic macular edema. Graefes Arch Clin Exp Ophthalmol 249:1627-33

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