The purpose of the LIFE Study is to assess the impact of environmental factors, broadly defined to include lifestyle factors, on human reproduction and development. The LIFE Study is consistent with the mission of the National Institute of Child Health and Human Development that includes conducting basic, clinical and epidemiologic research focusing on factors and processes associated with human reproduction and development thereby, ensuring the birth of healthy infants capable of reaching full adult potential unimpaired by physical or mental disabilities. This study is assessing the relation between select environmental factors and human fecundity and fertility, particularly in the context of lifestyle. 501 couples discontinuing contraception for purposes of becoming pregnant were recruited from 16 targeted counties in Michigan and Texas. Couples completed baseline interviews and standardized anthropometric assessments and were prospectively followed for up to 12 months attempting pregnancy. Pregnant women were followed until delivery. Couples provided blood and urine samples at baseline, and men provided semen samples and women saliva samples for the analysis of semen quality and stress biomarkers, respectively. Select blood metals (lead and cadmium) and serum organochlorine pollutants (PCBs and PFCs) chemicals were found to be associated with couple fecundity as measured by a longer time required for pregnancy. Male chemical concentrations were observed to be associated with greater reduction in fecundity. Analysis of short-lived chemicals and lifestyle is currently underway.

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Goldstone, Alexandra E; Chen, Zhen; Perry, Melissa J et al. (2015) Urinary bisphenol A and semen quality, the LIFE Study. Reprod Toxicol 51:13-Jul
Buck Louis, Germaine M; Sundaram, Rajeshwari; Schisterman, Enrique F et al. (2014) Semen quality and time to pregnancy: the Longitudinal Investigation of Fertility and the Environment Study. Fertil Steril 101:453-62
Buck Louis, Germaine M; Sundaram, Rajeshwari; Sweeney, Anne M et al. (2014) Urinary bisphenol A, phthalates, and couple fecundity: the Longitudinal Investigation of Fertility and the Environment (LIFE) Study. Fertil Steril 101:1359-66
Schisterman, E F; Mumford, S L; Chen, Z et al. (2014) Lipid concentrations and semen quality: the LIFE study. Andrology 2:408-15
Schisterman, Enrique F; Mumford, Sunni L; Browne, Richard W et al. (2014) Lipid concentrations and couple fecundity: the LIFE study. J Clin Endocrinol Metab 99:2786-94
Buck Louis, Germaine M (2014) Persistent environmental pollutants and couple fecundity: an overview. Reproduction 147:R97-R104
Buck Louis, Germaine M; Yeung, Edwina; Sundaram, Rajeshwari et al. (2013) The exposome--exciting opportunities for discoveries in reproductive and perinatal epidemiology. Paediatr Perinat Epidemiol 27:229-36