The purpose of the LIFE Study is to assess the impact of environmental factors, broadly defined to include lifestyle factors, on human reproduction and development. The LIFE Study is consistent with the mission of the National Institute of Child Health and Human Development that includes conducting basic, clinical and epidemiologic research focusing on factors and processes associated with human reproduction and development thereby, ensuring the birth of healthy infants capable of reaching full adult potential unimpaired by physical or mental disabilities. This study is assessing the relation between select environmental factors and human fecundity and fertility, particularly in the context of lifestyle. 501 couples discontinuing contraception for purposes of becoming pregnant were recruited from 16 targeted counties in Michigan and Texas. Couples completed baseline interviews and standardized anthropometric assessments and were prospectively followed for up to 12 months attempting pregnancy. Pregnant women were followed until delivery. Couples provided blood and urine samples at baseline, and men provided semen samples and women saliva samples for the analysis of semen quality and stress biomarkers, respectively. Select blood metals (lead and cadmium) and serum organochlorine pollutants (PCBs and PFCs) chemicals were found to be associated with couple fecundity as measured by a longer time required for pregnancy. Male chemical concentrations were observed to be associated with greater reduction in fecundity. Analysis of short-lived chemicals and lifestyle is currently underway.

Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2013
Total Cost
$112,721
Indirect Cost
City
State
Country
Zip Code
Louis, Germaine M Buck; Sapra, Katherine J; Barr, Dana Boyd et al. (2016) Preconception perfluoroalkyl and polyfluoroalkyl substances and incident pregnancy loss, LIFE Study. Reprod Toxicol 65:11-17
Buck Louis, Germaine M; Sapra, Katherine J; Schisterman, Enrique F et al. (2016) Lifestyle and pregnancy loss in a contemporary cohort of women recruited before conception: The LIFE Study. Fertil Steril 106:180-8
Sapra, Katherine J; Joseph, K S; Galea, Sandro et al. (2016) Signs and Symptoms of Early Pregnancy Loss: A Systematic Review. Reprod Sci :
Buck Louis, G M; Barr, D B; Kannan, K et al. (2016) Paternal exposures to environmental chemicals and time-to-pregnancy: overview of results from the LIFE study. Andrology 4:639-47
Smarr, Melissa M; Grantz, Katherine L; Zhang, Cuilin et al. (2016) Persistent organic pollutants and pregnancy complications. Sci Total Environ 551-552:285-91
Goldstone, Alexandra E; Chen, Zhen; Perry, Melissa J et al. (2015) Urinary bisphenol A and semen quality, the LIFE Study. Reprod Toxicol 51:7-13
Eisenberg, Michael L; Kim, Sungduk; Chen, Zhen et al. (2015) The relationship between male BMI and waist circumference on semen quality: data from the LIFE study. Hum Reprod 30:493-4
Louis, Germaine M Buck; Chen, Zhen; Schisterman, Enrique F et al. (2015) Perfluorochemicals and human semen quality: the LIFE study. Environ Health Perspect 123:57-63
Eisenberg, Michael L; Chen, Zhen; Ye, Aijun et al. (2015) Relationship between physical occupational exposures and health on semen quality: data from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study. Fertil Steril 103:1271-7
Robledo, Candace A; Yeung, Edwina; Mendola, Pauline et al. (2015) Preconception maternal and paternal exposure to persistent organic pollutants and birth size: the LIFE study. Environ Health Perspect 123:88-94

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