When data are clustered due to longitudinal follow up or repeated sampling, special statistical methods need to be used to avoid bias and inefficiency. While in some clustered data the cluster size is pre-determined, in others it may be varying and correlated to the outcome of subunits, resulting in informative cluster size. When the cluster size is informative, standard statistical procedures that ignore cluster size may produce biased estimates. In this PI-initiated project, we will compare several methods that have been proposed in the literature to model data with informative cluster size, including within-cluster resampling, cluster weighted GEE, and joint modeling.

Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2011
Total Cost
$70,000
Indirect Cost
City
State
Country
Zip Code
Louis, Germaine M Buck; Lum, Kirsten J; Sundaram, Rajeshwari et al. (2011) Stress reduces conception probabilities across the fertile window: evidence in support of relaxation. Fertil Steril 95:2184-9
Chen, Zhen; Zhang, Bo; Albert, Paul S (2011) A joint modeling approach to data with informative cluster size: robustness to the cluster size model. Stat Med 30:1825-36
Buck Louis, Germaine M; Hediger, Mary L; Peterson, C Matthew et al. (2011) Incidence of endometriosis by study population and diagnostic method: the ENDO study. Fertil Steril 96:360-5
Buck Louis, Germaine M; Schisterman, Enrique F; Sweeney, Anne M et al. (2011) Designing prospective cohort studies for assessing reproductive and developmental toxicity during sensitive windows of human reproduction and development--the LIFE Study. Paediatr Perinat Epidemiol 25:413-24
Munson, Jeffrey C; Kreider, Maryl; Chen, Zhen et al. (2010) Effect of treatment guidelines on the initial management of idiopathic pulmonary fibrosis. Br J Clin Pharmacol 70:118-25
Chetty-John, Shilpa; Zhang, Jun; Chen, Zhen et al. (2010) Long-term physical and neurologic development in newborn infants with isolated single umbilical artery. Am J Obstet Gynecol 203:368.e1-7
Platt, Alec B; Kuna, Samuel T; Field, Samuel H et al. (2010) Adherence to sleep apnea therapy and use of lipid-lowering drugs: a study of the healthy-user effect. Chest 137:102-8
Munson, Jeffrey C; Kreider, Maryl; Chen, Zhen et al. (2010) Factors associated with the use of corticosteroids in the initial management of idiopathic pulmonary fibrosis. Pharmacoepidemiol Drug Saf 19:756-62
Muntner, Paul; Anderson, Amanda; Charleston, Jeanne et al. (2010) Hypertension awareness, treatment, and control in adults with CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 55:441-51
Levine, Joshua; Kofke, Andrew; Cen, Liyi et al. (2010) Red blood cell transfusion is associated with infection and extracerebral complications after subarachnoid hemorrhage. Neurosurgery 66:312-8; discussion 318