This year, under this project we developed a new form of x-ray imaging system capable of detecting the refractive bending of x-rays at sub-nanoradian resolution. It is based on the nanometric x-ray gratings we have developed in the recent past. This type of imager can potentially see structures that are transparent to conventional x-ray machines. In the past such sensitivity has been achieved with special x-ray sources of very narrow bandwidths. With the new system the restrictions on the bandwidth and collimation of the x-ray beam are removed, which advances the concept towards compact systems for benchtop pre-clinical applications.

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National Heart, Lung, and Blood Institute
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Miao, Houxun; Chen, Lei; Mirzaeimoghri, Mona et al. (2016) Cryogenic Etching of High Aspect Ratio 400 nm Pitch Silicon Gratings. J Microelectromech Syst 25:963-967
Miao, Houxun; Panna, Alireza; Gomella, Andrew A et al. (2016) A Universal Moiré Effect and Application in X-Ray Phase-Contrast Imaging. Nat Phys 12:830-834
Harmon, Katherine J; Miao, Houxun; Gomella, Andrew A et al. (2015) Motionless electromagnetic phase stepping versus mechanical phase stepping in x-ray phase-contrast imaging with a compact source. Phys Med Biol 60:3031-43
Nayak, Krishna S; Nielsen, Jon-Fredrik; Bernstein, Matt A et al. (2015) Cardiovascular magnetic resonance phase contrast imaging. J Cardiovasc Magn Reson 17:71
Miao, Houxun; Gomella, Andrew A; Harmon, Katherine J et al. (2015) Enhancing Tabletop X-Ray Phase Contrast Imaging with Nano-Fabrication. Sci Rep 5:13581
Miao, Houxun; Gomella, Andrew A; Chedid, Nicholas et al. (2014) Fabrication of 200 nm period hard X-ray phase gratings. Nano Lett 14:3453-8
Wen, Han; Gomella, Andrew A; Patel, Ajay et al. (2014) Boosting phase contrast with a grating Bonse-Hart interferometer of 200 nanometre grating period. Philos Trans A Math Phys Eng Sci 372:20130028
Harmon, Katherine J; Bennett, Eric E; Gomella, Andrew A et al. (2014) Efficient decoding of 2D structured illumination with linear phase stepping in X-ray phase contrast and dark-field imaging. PLoS One 9:e87127
Wen, Han; Wolfe, Douglas E; Gomella, Andrew A et al. (2013) Interferometric hard x-ray phase contrast imaging at 204 nm grating period. Rev Sci Instrum 84:013706
Gomella, Andrew; Martin, Eric W; Lynch, Susanna K et al. (2013) Low dose hard x-ray contact microscopy assisted by a photoelectric conversion layer. AIP Adv 3:42121

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