This year, under this project we developed a new form of x-ray imaging system capable of detecting the refractive bending of x-rays at sub-nanoradian resolution. It is based on the nanometric x-ray gratings we have developed in the recent past. This type of imager can potentially see structures that are transparent to conventional x-ray machines. In the past such sensitivity has been achieved with special x-ray sources of very narrow bandwidths. With the new system the restrictions on the bandwidth and collimation of the x-ray beam are removed, which advances the concept towards compact systems for benchtop pre-clinical applications.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
National Heart, Lung, and Blood Institute
Zip Code
Miao, Houxun; Gomella, Andrew A; Chedid, Nicholas et al. (2014) Fabrication of 200 nm period hard X-ray phase gratings. Nano Lett 14:3453-8
Wen, Han; Gomella, Andrew A; Patel, Ajay et al. (2014) Boosting phase contrast with a grating Bonse-Hart interferometer of 200 nanometre grating period. Philos Trans A Math Phys Eng Sci 372:20130028
Harmon, Katherine J; Bennett, Eric E; Gomella, Andrew A et al. (2014) Efficient decoding of 2D structured illumination with linear phase stepping in X-ray phase contrast and dark-field imaging. PLoS One 9:e87127
Gomella, Andrew; Martin, Eric W; Lynch, Susanna K et al. (2013) Low dose hard x-ray contact microscopy assisted by a photoelectric conversion layer. AIP Adv 3:42121
Wen, Han; Wolfe, Douglas E; Gomella, Andrew A et al. (2013) Interferometric hard x-ray phase contrast imaging at 204 nm grating period. Rev Sci Instrum 84:013706
Wen, Han; Bennett, Eric E; Hegedus, Monica M et al. (2009) Fourier X-ray scattering radiography yields bone structural information. Radiology 251:910-8
Wen, Han; Bennett, Eric E; Hegedus, Monica M et al. (2008) Spatial harmonic imaging of X-ray scattering--initial results. IEEE Trans Med Imaging 27:997-1002