Our lab is engaged in collaborations with clinical groups to examine behavior in patients with schizophrenia and Parkinsons disease, using tasks which engage frontal-striatal systems to see if patients show deficits in these tasks. Our strategy is to identify behavioural deficits in patient groups, and then to pursue those deficits using neuroscientific tools, to try to understand the mechanisms that underlie the behavioral differences in groups. Specifically, we carry out behavioural studies in patient groups to identify tasks that differentiate patient and control groups. Once these behaviours have been identified, we can use neuroimaging to identify the brain regions that are responding differently in the control and patients groups. We can also use pharmacological manipulations in control groups to try to modify their behaviour to match the patient group. Following that, more detailed techniques can be used to try to examine the circuit mechanisms that underlie the differences in behaviour between the groups. The ultimate goal is to examine the effects of neuromodulators at the micro-circuit level, and to link changes in processing at the microcircuit level to changes in behaviour, to help elucidate the pathology that underlies schizophrenia, Parkinson's disease and related disorders.

Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2013
Total Cost
$1,258,395
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
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Country
Zip Code
de Rezende Costa, Flavio Henrique; Averbeck, Bruno; O'Sullivan, Sean S et al. (2016) Jumping to conclusions in untreated patients with Parkinson's disease. Neuropsychologia 85:19-23
Kahn, Kevin; Saxena, Shreya; Eskandar, Emad et al. (2015) A systematic approach to selecting task relevant neurons. J Neurosci Methods 245:156-68
Michalopoulou, Panayiota G; Averbeck, Bruno B; Kalpakidou, Anastasia K et al. (2015) The effects of a single dose of oxytocin on working memory in schizophrenia. Schizophr Res 162:62-3
Fukushima, Makoto; Doyle, Alex M; Mullarkey, Matthew P et al. (2015) Distributed acoustic cues for caller identity in macaque vocalization. R Soc Open Sci 2:150432
Averbeck, Bruno B (2015) Theory of choice in bandit, information sampling and foraging tasks. PLoS Comput Biol 11:e1004164
Jang, Anthony I; Costa, Vincent D; Rudebeck, Peter H et al. (2015) The Role of Frontal Cortical and Medial-Temporal Lobe Brain Areas in Learning a Bayesian Prior Belief on Reversals. J Neurosci 35:11751-60
Liu, Ning; Hadj-Bouziane, Fadila; Jones, Katherine B et al. (2015) Oxytocin modulates fMRI responses to facial expression in macaques. Proc Natl Acad Sci U S A 112:E3123-30
Lee, Eunjeong; Seo, Moonsang; Dal Monte, Olga et al. (2015) Injection of a dopamine type 2 receptor antagonist into the dorsal striatum disrupts choices driven by previous outcomes, but not perceptual inference. J Neurosci 35:6298-306
Dal Monte, Olga; Costa, Vincent D; Noble, Pamela L et al. (2015) Amygdala lesions in rhesus macaques decrease attention to threat. Nat Commun 6:10161
Costa, Vincent D; Tran, Valery L; Turchi, Janita et al. (2015) Reversal learning and dopamine: a bayesian perspective. J Neurosci 35:2407-16

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