Although the underlying mechanisms of fatigue have been studied in several disease conditions, the data are not conclusive, and this symptom remains poorly managed at present. Longitudinal studies related to treatment-related fatigue in prostate cancer patients have been conducted, but there are limited studies exploring the changes in physiologic mechanisms before and after radiotherapy which can identify individuals who are at risk for enduring fatigue during and after therapy. Fatigue is conceptualized as a multidimensional symptom which incorporates temporal, sensory, cognitive/mental, affective/emotional, behavioral, and physiological dimensions. This prospective, observational study is the first study to explore the molecular-genetic mechanisms underlying fatigue and the cluster of symptoms (urinary, sexual, gastrointestinal, psychiatric) experienced by prostate cancer patients undergoing External Beam Radiation Therapy (EBRT). The primary objective of the study is to describe the changes in the self-reported fatigue;urinary, sexual, and gastrointestinal symptoms;depression;fatigue catastrophizing;and health-related quality of life (HRQOL) experienced by patients with and without prostate surgery before, during, and after EBRT completion. The secondary objectives of this study are to investigate the pro-inflammatory cytokine profile of EBRT-related fatigue (TNF, IGF-I, IL-6, IL-8, TGF and ) and to determine changes in white blood cell gene expression using buffy coat collection before, during, and after EBRT completion and to relate these changes in the levels of these biological markers to self-reported fatigue;urinary, sexual, and gastrointestinal symptoms;depression;fatigue catastrophizing;and HRQOL scores. This study also aims to measure the skeletal muscle strength, activity levels and energy expenditure of patients before, during, and at completion of EBRT and relate these findings with self-reported fatigue, physical symptoms (e.g. urinary, gastrointestinal, and sexual functioning), depression, and HRQOL scores.

Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2012
Total Cost
$167,369
Indirect Cost
Name
National Institute of Nursing Research
Department
Type
DUNS #
City
State
Country
Zip Code
Wolff, Brian S; Renner, Michael A; Springer, Danielle A et al. (2017) A Mouse Model of Fatigue Induced by Peripheral Irradiation. J Vis Exp :
Dougherty, John P; Wolff, Brian S; Cullen, Mary J et al. (2017) Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue. Pharmacol Res 124:1-8
Saligan, Leorey N; Luckenbaugh, David A; Slonena, Elizabeth E et al. (2016) An assessment of the anti-fatigue effects of ketamine from a double-blind, placebo-controlled, crossover study in bipolar disorder. J Affect Disord 194:115-9
Renner, Michael; Feng, Rebekah; Springer, Danielle et al. (2016) A murine model of peripheral irradiation-induced fatigue. Behav Brain Res 307:218-26
Ortiz, Robin; Ballard, Elizabeth D; Machado-Vieira, Rodrigo et al. (2016) Quantifying the influence of child abuse history on the cardinal symptoms of fibromyalgia. Clin Exp Rheumatol 34:S59-66
Cashion, Ann K; Gill, Jessica; Hawes, Rebecca et al. (2016) National Institutes of Health Symptom Science Model sheds light on patient symptoms. Nurs Outlook 64:499-506
Lukkahatai, Nada; Walitt, Brian; Espina, Alexandra et al. (2016) Understanding the Association of Fatigue With Other Symptoms of Fibromyalgia: Development of a Cluster Model. Arthritis Care Res (Hoboken) 68:99-107
Lukkahatai, Nada; Walitt, Brian; Espina, Alexandra et al. (2015) Comparing Genomic Profiles of Women With and Without Fibromyalgia. Biol Res Nurs 17:373-83
Saligan, Leorey N (2014) The relationship between physical activity, functional performance and fatigue in sarcoidosis. J Clin Nurs 23:2376-8
Lukkahatai, Nada; Majors, Benjamin; Reddy, Swarnalatha et al. (2013) Gene expression profiles of fatigued fibromyalgia patients with different categories of pain and catastrophizing: a preliminary report. Nurs Outlook 61:216-224.e2

Showing the most recent 10 out of 15 publications