The Vaccine Research Center Immunology Core provides a service facility which supports the vaccine development program of the VRC. Through the in depth analysis of vaccine-induced immune responses, the Immunology Core provides information to the vaccine development program at the VRC which is crucial to the development of new and better immunogens. The Immunology Core works on T and B cell responses to Influenza, HIV, Ebola, and other pathogens as needed to support the vaccine effort of the VRC. An examples of the type of data that can be generated are the frequency of B cells specific for different Influenza epitopes in response to different Flu vaccine modalities.

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Ledgerwood, Julie E; Hu, Zonghui; Costner, Pamela et al. (2015) Phase I Clinical Evaluation of Seasonal Influenza Hemagglutinin (HA) DNA Vaccine Prime Followed by Trivalent Influenza Inactivated Vaccine (IIV3) Boost. Contemp Clin Trials :
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Liang, Frank; Ploquin, Aurélie; Hernández, José DelaO et al. (2015) Dissociation of skeletal muscle for flow cytometric characterization of immune cells in macaques. J Immunol Methods 425:69-78
Kibuuka, Hannah; Berkowitz, Nina M; Millard, Monica et al. (2015) Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, placebo-controlled clinical trial. Lancet 385:1545-54
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