The Postmortem Pathology Section provides a complete, 24 hour per day, 365 days per year service in autopsy pathology for the Clinical Center. All patients on protocols for any of the Institutes or the Clinical Center may have an autopsy performed by the Laboratory of Pathology at the discretion of the principle investigator. The results from autopsies are used to assess treatment response, to answer clinical questions at the time of death, to identify pathology that was unknown or misdiagnosed prior to death, and to provide for hospital and protocol quality assurance. In addition, when the use and study of human pathological material is requested by research staff of any of the categorical institutes, the Postmortem Section makes every effort to collaborate with and/or supply the researchers with the human tissues upon approved request. (The Laboratory of Pathology has a standard procedure for tissue requests.) The autopsy material is utilized by staff and residents for research projects involving clinicopathological correlation and characterization of disease processes. Currently, several projects are on-going: clinical-pathological studies in dementia;culture of glioma stem cells from post-mortem tumor specimens;MRI correlations with normal tissue and de-myelinating disease (multiple sclerosis);investigation into Job syndrome and chronic granulomatous disease;characterization of pulmonary pathology in patients with non-tuberculous mycobacterial infection and complications of graft-versus-host disease. A partial database of major autopsy findings from 1953 through the present is available and all findings from March, 1999 on are available on-line through the Laboratory of Pathology's Information System. This system contains the full text of all autopsy reports. Texts of final reports are also available in the Clinical Research Information System (CRIS) after sign-out. In addition to its primary clinical responsibilities and research support function, the Post-mortem Pathology section is responsible for training pathology residents in the art and science of autopsy pathology.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICBC010685-07
Application #
8350103
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2011
Total Cost
$568,336
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Kleiner, David E (2017) On beyond staging and grading: Liver biopsy evaluation in a posttreatment world. Hepatology 65:1432-1434
Kleiner, David E (2017) Drug-induced Liver Injury: The Hepatic Pathologist's Approach. Gastroenterol Clin North Am 46:273-296
Kleiner, David E (2017) The Role of the Hepatopathologist in the Assessment of Drug-induced Liver Injury. Clin Liver Dis (Hoboken) 9:34-37
Kleiner, David E; Makhlouf, Hala R (2016) Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Adults and Children. Clin Liver Dis 20:293-312
Brown, Gregory Thomas; Kleiner, David E (2016) Histopathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Metabolism 65:1080-6
Angulo, Paul; Kleiner, David E; Dam-Larsen, Sanne et al. (2015) Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology 149:389-97.e10
Elinoff, Jason M; Bagci, Ulas; Moriyama, Brad et al. (2014) Recombinant human factor VIIa for alveolar hemorrhage following allogeneic stem cell transplantation. Biol Blood Marrow Transplant 20:969-78
Oppenheimer, Ana Paula; Koh, Christopher; McLaughlin, Mary et al. (2013) Vanishing bile duct syndrome in human immunodeficiency virus infected adults: a report of two cases. World J Gastroenterol 19:115-21
O'Connell, Meghan L; Birkenkamp, Kate E; Kleiner, David E et al. (2012) Lung manifestations in an autopsy-based series of pulmonary or disseminated nontuberculous mycobacterial disease. Chest 141:1203-9
Koh, C; Hipp, J D; Kleiner, D E et al. (2010) Acute right upper quadrant pain: a lesson in odds. Dig Liver Dis 42:72-3

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