We demonstrated that functional infrared imaging is capable of detecting low frequency temperature fluctuations in intact human skin and revealing spatial, temporal, spectral, and time-frequency based differences among three tissue classes: microvasculature, large sub-cutaneous veins, and the remaining surrounding tissue of the forearm. We found that large veins have stronger contractility in the range of 0.005-0.06 Hz compared to the other two tissue classes. Wavelet phase coherence and power spectrum correlation analysis show that microvasculature and skin areas without vessels visible by IR have high phase coherence in the lowest three frequency ranges (0.005-0.0095 Hz, 0.0095-0.02 Hz, and 0.02-0.06 Hz), whereas large veins oscillate independently. A clinical protocol is underway to try to associate temperature oscillations with oscillations of microcirculation measured by laser speckle imaging.

Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2013
Total Cost
$28,335
Indirect Cost
Name
National Institute of Biomedical Imaging and Bioengineering
Department
Type
DUNS #
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Chang, Ken; Yoon, Stephen; Sheth, Niral et al. (2015) Rapid vs. delayed infrared responses after ischemia reveal recruitment of different vascular beds. Quant Infrared Thermogr J 12:173-183
Webb, R Chad; Ma, Yinji; Krishnan, Siddharth et al. (2015) Epidermal devices for noninvasive, precise, and continuous mapping of macrovascular and microvascular blood flow. Sci Adv 1:e1500701
Balageas, Daniel L; Roche, Jean-Michel; Leroy, François-Henri et al. (2015) THE THERMOGRAPHIC SIGNAL RECONSTRUCTION METHOD: A POWERFUL TOOL FOR THE ENHANCEMENT OF TRANSIENT THERMOGRAPHIC IMAGES. Biocybern Biomed Eng 35:1-9
Liu, Wei-Min; Maivelett, Jordan; Kato, Gregory J et al. (2012) Reconstruction of Thermographic Signals to Map Perforator Vessels in Humans. Quant Infrared Thermogr J 9:123-133