Behavioral neuroscience links systems-level circuitry to behavior, cognition and emotion, and is thus critical for understanding the afflictions that affect neuropsychiatric patients. Linking cognitive changes in a behaving rat or mouse to targeted manipulations of neural circuitry requires the convergence of expertise from scientific fields inside and outside of neuroscience. In designing research projects to understand the anatomy, genetics, and pharmacology underlying the control of behavior, researchers must understand the nature of the task, its measurements, and how to interpret the data. Several steps lie between the the design of the experiment and the behavioral output including choice of task (e.g., operant vs mazes), how to train the animal (shaping vs conditioning), the type of surgical manipulation (ablation, cannulation, inactivation, stimulation, etc), and the format of data for analysis (summary vs trial-by-trial). Most neuroscience researchers who use standard off-the-shelf behavioral tasks like forced swim, rotarod and T-Maze are not experts in the psychology of behavior and therefore rely on experts in the domain of cognition. Complex cognitive behavior in rodents is often gauged by measuring the pattern of behavioral responses in tasks that involve, for example, decision-making, attention, memory, rule learning, flexibility, discrimination, and problem solving. In these tasks, rats and mice typically indicate their decisions by nose-poking visual patterns on a touchscreen like an iPad, making nose-poke entries into a series of lit holes, or depressing an extended lever triggered by time or cues. Some cognitive functions extrapolated from animal behavior have positively informed our investigation of cognitive functions in humans. Such animal-to-human approaches (e.g., delayed response) have directed the design and development of analogous tests for use in humans (e.g., self-ordered working memory). Behavioral neuroscience has also benefitted in the opposite direction by means of human-to-animal approaches as in the case of extradimensionsal/intradimensional set shifting, a test based upon the principles of the human Wisconsin Card Sorting Task. Together, these advances in behavioral testing have been particularly useful in terms of establishing the neuroanatomical and neurochemical pathology for specific cognitive deficits in a range of brain and behavior disorders. In addition to providing equipment, training and consulting for researchers interested in using rodents as models to investigate disorders of brain and behavior, one important goal for the RBC is to continue to design and develop cutting edge behavioral methods and applications while maintaining a high level of utility of the facility resources for users at all levels of expertise. This high level of utility requires constant maintenance and calibration of equipment, user education and interaction, and commitment to setting the standard as the best Rodent Behavioral Core facility in the world in terms of research quality. Since its inception, several PIs from NIMH as well as NINDS, NHGRI and NICHD have inquired about using the RBC to conduct specific behavioral studies in an efficient and targeted manner. We expect full capacity once the installation of the equipment insfratructure is complete. The RBC was initiated in Nov 2015, and near complete in its renovations and equipment infrastructure in Aug 2016. A staff scientist and technician were hired to support the operations and maintenance of the core.
