The project serves to coordinate the training and the university-NIH interface. The project provides trainees with molecular and comparative pathology educational content suitable for graduate credit at partnership universities. Staff within the Molecular Pathology Unit have a significant responsibility in training and mentoring trainees. Trainees undertake pre-dissertation research within the molecular pathology unit for which they receive university graduate course credit. The veterinary pathologists undertaking research training integrate pathology into the range of intramural research. Integration of the veterinary pathologist into the laboratory results in fulfillment of the training programs vision of vertically integrated pathologist-investigator, working in partnership as research team member from discovery to research translation. The educational infrastructure within the training consortium includes university collaboration and builds upon an interdisciplinary orientation to team science. Program and trainee accomplishments for fiscal year 2009 include: Accomplishments 1. Addition of 5th US college of veterinary medicine to the training partnership: Purdue University, West Lafayette, Indiana. 2. Recruited 2 veterinarians to initiate Graduate Partnership Program training - one at Purdue University, West Layfayette, IN and one at Michigan State University, East Lansing, MI. 3. Program trainees authored or co-authored 10 peer-reviewed scientific journal articles 8 research, 1 review and 1 clinical articles published in journals including: Neoplasia, Cancer Cell, Cell Stem Cell, Oncogene, Cancer, and Toxicologic Pathology. 4. 3 Young Investigator Awards 2008-2009. 5. One trainee successfully completed national specialty board certification examination by The American College of Veterinary Pathologists. 6. Five veterinary students trained during summer internships or clerkships within the training program. 7. Comparative Biomedical Scientist Training Program Symposium, held October 2-3, 2008, organized by Molecular Pathology Unit, LCBG

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Animal Research Infrastructure Intramural Research (ZIG)
Project #
1ZIGBC010931-02
Application #
7970357
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2009
Total Cost
$1,045,163
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Martin, P L; Yin, J-J; Seng, V et al. (2017) Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer. Oncogene 36:525-533
Wei, Bih-Rong; Michael, Helen T; Halsey, Charles H C et al. (2016) Synergistic targeted inhibition of MEK and dual PI3K/mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma. Pigment Cell Melanoma Res :
LeBlanc, Amy K; Mazcko, Christina; Brown, Diane E et al. (2016) Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients. Neuro Oncol 18:1209-18
Ramos-Vara, J A; Webster, J D; DuSold, D et al. (2014) Immunohistochemical evaluation of the effects of paraffin section storage on biomarker stability. Vet Pathol 51:102-9
Simpson, R Mark; Bastian, Boris C; Michael, Helen T et al. (2014) Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma. Pigment Cell Melanoma Res 27:37-47
Geiger, Thomas R; Ha, Ngoc-Han; Faraji, Farhoud et al. (2014) Functional analysis of prognostic gene expression network genes in metastatic breast cancer models. PLoS One 9:e111813
Zhang, Shuling; Pruitt, Margaret; Tran, Dena et al. (2013) B cell-specific deficiencies in mTOR limit humoral immune responses. J Immunol 191:1692-703
Cramer, Sarah D; Campbell, Gregory A; Gray, Charles W et al. (2012) Pathology in practice. Brain neoplasm. J Am Vet Med Assoc 240:47-9
Wei, Bih-Rong; Simpson, R Mark; Johann, Donald J et al. (2012) Proteomic profiling of H-Ras-G12V induced hypertrophic cardiomyopathy in transgenic mice using comparative LC-MS analysis of thin fresh-frozen tissue sections. J Proteome Res 11:1561-70
Sharkey, L C; Simpson, R M; Wellman, M L et al. (2012) The value of biomedical research training for veterinary anatomic and clinical pathologists. Vet Pathol 49:581-5

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