1. To evaluate promising lead compounds for treating drug dependence through a broad panel of receptor and enzyme targets (Profile) in order to identify potential side effect liabilities and/or characterize the selectivity of the compounds for the desired pharmacological target set (Task 1). 2. To perform binding affinity and/or functional activity assessments of active compounds (Task 2). 3. To evaluate test compounds in a set of toxicological and pharmacokinetic assays in order to judge their potential for development as future therapeutic agents. These compounds and assays will be evaluated under Task 3. 4. Large compound libraries will be screened against a single target. (Task 4).

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research and Development Contracts (N01)
Project #
271200800001I-1-9999-1
Application #
7943305
Study Section
Project Start
2008-09-25
Project End
2013-09-28
Budget Start
Budget End
Support Year
Fiscal Year
2009
Total Cost
$176,792
Indirect Cost
Name
Novascreen Biosciences Corporation
Department
Type
DUNS #
621176254
City
Hanover
State
MD
Country
United States
Zip Code
21076