This proposal is for years 21-25 of the Harvard AITRP, which proposes strong HIV/AIDS research training for applicants from 6 developing countries: Botswana, China, Nigeria, Senegal, Tanzania, and Thailand. The training is linked to specific sites and collaborators in these countries where active research collaborations are well established. Most of the faculty are associated with the Harvard School of Public Health (HSPH), which has extensive experience training students from developing countries. The research training is multidisciplinary, and linked to problems of prevention and treatment, including design of clinical trials, surveillance, mother-to-child transmission and chemoprophylaxis, vaccine design, drug efficacy and toxicity, drug resistance, behavioral issues, and HIV/AIDS health policy and cost effectiveness. The educational focus is on pre- and postdoctoral training in AIDS research, as well as shorter-term training in both Boston and the foreign sites. In the latter case, selected earlier AITRP trainees will be involved in south-to-south training in the developing country sites. The large number of foreign health professionals who have trained at HSPH serve, along with developing country collaborators, as a network for applicant referrals. The faculty advisors for the program have expertise in epidemiology (9), infectious diseases (7), immunology or virology (7), behavioral sciences (5), biostatistics (3), ethics (1), and international policy and economics (3). Most faculty members listed have active collaborations in one or more of the developing countries cited as partner countries, and have mentored trainees in the past. Numerous AIDS related courses, seminars, and workshops are available for trainees. Each trainee will have a principal advisor and a faculty advisory committee. Selection of trainees under a selection committee is based on previous academic performance, references, experience, and assurance that the candidates will return to participate in AIDS research in a developing country. The quality of the program will be monitored by a Training Advisory Group composed of experts from the US and from developing countries. ? ? ?

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
2D43TW000004-21
Application #
7487663
Study Section
Special Emphasis Panel (ZRG1-BDA-K (50))
Program Officer
Mcdermott, Jeanne
Project Start
1993-09-21
Project End
2013-05-31
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
21
Fiscal Year
2008
Total Cost
$814,329
Indirect Cost
Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Public Health
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Cespedes, Michelle S; Kang, Minhee; Kojic, Erna Milunka et al. (2018) Anogenital human papillomavirus virus DNA and sustained response to the quadrivalent HPV vaccine in women living with HIV-1. Papillomavirus Res 6:15-21
Xie, Wen; Agniel, Denis; Shevchenko, Andrey et al. (2017) Genome-Wide Analyses Reveal Gene Influence on HIV Disease Progression and HIV-1C Acquisition in Southern Africa. AIDS Res Hum Retroviruses 33:597-609
Erlandson, Kristine M; Fiorillo, Suzanne; Masawi, Fadzai et al. (2017) Antiretroviral initiation is associated with increased skeletal muscle area and fat content. AIDS 31:1831-1838
Kiser, Jennifer J; Lu, Darlene; Rosenkranz, Susan L et al. (2017) Boceprevir and Antiretroviral Pharmacokinetic Interactions in HIV/HCV Co-infected Persons: AIDS Clinical Trials Group Study A5309s. Drugs R D 17:557-567
Kaaya, Sylvia; Garcia, Maria E; Li, Nan et al. (2016) Association of maternal depression and infant nutritional status among women living with HIV in Tanzania. Matern Child Nutr 12:603-13
Rossenkhan, Raabya; MacLeod, Iain J; Brumme, Zabrina L et al. (2016) Transmitted/Founder HIV-1 Subtype C Viruses Show Distinctive Signature Patterns in Vif, Vpr, and Vpu That Are Under Subsequent Immune Pressure During Early Infection. AIDS Res Hum Retroviruses 32:1031-1045
Powis, Kathleen M; Smeaton, Laura; Hughes, Michael D et al. (2016) In-utero triple antiretroviral exposure associated with decreased growth among HIV-exposed uninfected infants in Botswana. AIDS 30:211-20
Novitsky, Vlad; Bussmann, Hermann; Okui, Lillian et al. (2015) Estimated age and gender profile of individuals missed by a home-based HIV testing and counselling campaign in a Botswana community. J Int AIDS Soc 18:19918
Mwiru, Ramadhani S; Spiegelman, Donna; Duggan, Christopher et al. (2015) Nutritional Status and Other Baseline Predictors of Mortality among HIV-Infected Children Initiating Antiretroviral Therapy in Tanzania. J Int Assoc Provid AIDS Care 14:172-9
Novitsky, Vlad; Kühnert, Denise; Moyo, Sikhulile et al. (2015) Phylodynamic analysis of HIV sub-epidemics in Mochudi, Botswana. Epidemics 13:44-55

Showing the most recent 10 out of 159 publications