Abstract

We propose to continue our Fogarty AIDS International Training and Research Program (AITRP) at the University of Pittsburgh (Pitt) Graduate School of Public Health. The mission of the Pitt AITRP is to provide Brazilian and Indian health professionals with the multidisciplinary tools needed to conduct cutting-edge HIV prevention research in their countries of origin. The program Director is Dr. Lee Harrison, Professor of Epidemiology and Medicine. The program Co-Director is Dr. Phalguni Gupta, Professor of Infectious Diseases and Microbiology. ? ? Although our Brazilian trainees engage in many areas of HIV prevention research, a current focus of our program is studies of antiretroviral therapy (ART) in resource-limited countries. Current projects include studies of the effectiveness of ART and the increase in chronic diseases among patients living longer with HIV as a result of effective ART. ? ? In India, our program focuses on studies of the genetic heterogeneity of HIV in India, CD8 suppression of HIV, HIV incidence studies to identify high-risk populations, and the development of a novel Clostridium perfringens-based oral vaccine to induce mucosal immunity against HIV and SIV. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW001038-09
Application #
7245883
Study Section
Special Emphasis Panel (ZRG1-ICP-3 (02))
Program Officer
Mcdermott, Jeanne
Project Start
1998-09-30
Project End
2009-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
9
Fiscal Year
2007
Total Cost
$375,999
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Bollela, V R; Namburete, E I; Feliciano, C S et al. (2016) Detection of katG and inhA mutations to guide isoniazid and ethionamide use for drug-resistant tuberculosis. Int J Tuberc Lung Dis 20:1099-104
Sankapal, Soni; Gupta, Phalguni; Ratner, Deena et al. (2016) HIV Exposure to the Epithelia in Ectocervical and Colon Tissues Induces Inflammatory Cytokines Without Tight Junction Disruption. AIDS Res Hum Retroviruses 32:1054-1066
Guha, Debjani; Klamar, Cynthia R; Reinhart, Todd et al. (2015) Transcriptional Regulation of CXCL5 in HIV-1-Infected Macrophages and Its Functional Consequences on CNS Pathology. J Interferon Cytokine Res 35:373-84
Tarafdar, Sreya; Poe, Jerrod A; Smithgall, Thomas E (2014) The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner. J Biol Chem 289:15718-28
Dubé, Karine; Zango, Arlinda; van de Wijgert, Janneke et al. (2014) HIV incidence in a cohort of women at higher risk in Beira, Mozambique: prospective study 2009-2012. PLoS One 9:e84979
Zango, Arlinda; Dubé, Karine; Kelbert, Sílvia et al. (2013) Determinants of prevalent HIV infection and late HIV diagnosis among young women with two or more sexual partners in Beira, Mozambique. PLoS One 8:e63427
Millard, P S; Wilson, H R; Veldkamp, P J et al. (2013) Rapid, minimally invasive adult voluntary male circumcision: A randomised trial. S Afr Med J 103:736-42
Biswas, Nabanita; Wang, Tianyi; Ding, Ming et al. (2012) ADAR1 is a novel multi targeted anti-HIV-1 cellular protein. Virology 422:265-77
Kesinger, Matthew; Millard, Peter S (2012) Voluntary male medical circumcision. S Afr Med J 102:123-4
Millard, Peter S; Fumo, Afonso; Sabino, Elis (2012) Minimally invasive childhood and adult circumcision. Trop Doct 42:23-4

Showing the most recent 10 out of 25 publications