Our Global Infectious Diseases Research Training Program builds upon our sustained 20 year collaborations at the University of Virginia with the Federal University of Ceara in Fortaleza, Brazil, and upon our identification of key needs and gaps in research capacity and opportunities raised by our findings of long-term effects of endemic enteric and parasitic infections there. The program goal is to build relevant laboratory, clinical trials and genetic epidemiology expertise to fill gaps and needs in these areas and to strengthen the capacity of the Federal University of Ceara, in order to provide key new data to instruct policy on controlling endemic enteric and parasitic infections and their lasting consequences. Our research themes will focus upon the key areas of need and opportunity: genetic epidemiology and clinical trials. The training of carefully selected, competing postdoctoral fellows is enriched by special activities of this program, including an expanded 2 semester course on microbial pathogenesis, immunology, genetics and clinical trials courses and colloquia, a research-in-progress series, and a journal club, Our model of sustained international training and collaboration has resulted in a track record of 100% return of international trainees to become leaders in relevant research and excellence in centers in their home countries. All too often international training means providing opportunities for overseas physicians and scientists to be moved permanently to the U.S. (the typical problem of the """"""""brain drain""""""""). Our strongly articulated philosophy and documented track record is precisely the opposite: to attract the brightest and most innovative researchers who are strongly committed and have positions to which they prepare to return because the global infectious diseases problems on which they work present greater opportunities in their home countries.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Grants (D43)
Project #
5D43TW006578-02
Application #
6800027
Study Section
Special Emphasis Panel (ZRG1-ICP-2 (90))
Program Officer
Sina, Barbara J
Project Start
2003-09-05
Project End
2008-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
2
Fiscal Year
2004
Total Cost
$150,000
Indirect Cost
Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Etta, Elizabeth M; Alayande, Doyinmola P; Mavhandu-Ramarumo, Lufuno G et al. (2018) HHV-8 Seroprevalence and Genotype Distribution in Africa, 1998?2017: A Systematic Review. Viruses 10:
Bolick, D T; Medeiros, P H Q S; Ledwaba, S E et al. (2018) The Critical Role of Zinc in a New Murine Model of Enterotoxigenic E. coli (ETEC) Diarrhea. Infect Immun :
Ngobeni, Renay; Samie, Amidou (2017) PREVALENCE OF TOXOPLASMA GONDII IGG AND IGM AND ASSOCIATED RISK FACTORS AMONG HIV-POSITIVE AND HIV-NEGATIVE PATIENTS IN VHEMBE DISTRICT OF SOUTH AFRICA. Afr J Infect Dis 11:1-9
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Ngobeni, Renay; Abhyankar, Mayuresh M; Jiang, Nona M et al. (2017) Entamoeba histolytica-Encoded Homolog of Macrophage Migration Inhibitory Factor Contributes to Mucosal Inflammation during Amebic Colitis. J Infect Dis 215:1294-1302
Modipane, Mahlatse B; Waldman, Ava Lena; Ritterband, Lee et al. (2016) Technology Use Among Patients in a Nonurban Southern U.S. HIV Clinic in 2015. Telemed J E Health 22:965-968
Bolick, David T; Kolling, Glynis L; Moore 2nd, John H et al. (2014) Zinc deficiency alters host response and pathogen virulence in a mouse model of enteroaggregative Escherichia coli-induced diarrhea. Gut Microbes 5:618-27
Azevedo, Orleâncio G R; Bolick, David T; Roche, James K et al. (2014) Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice. PLoS One 9:e89562
Bolick, David T; Chen, Tufeng; Alves, Luís Antonio O et al. (2014) Intestinal cell kinase is a novel participant in intestinal cell signaling responses to protein malnutrition. PLoS One 9:e106902
Medeiros, Pedro; Bolick, David T; Roche, James K et al. (2013) The micronutrient zinc inhibits EAEC strain 042 adherence, biofilm formation, virulence gene expression, and epithelial cytokine responses benefiting the infected host. Virulence 4:624-33

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