Our Global Infectious Disease research training program has focused on mitigating leishmaniasis and other vector-borne and emerging infectious diseases in Colombia and the Latin American Region through basic, clinical, and translational research and training. The challenges of prevention and control of infectious diseases in Colombia and other low and middle income countries, require innovation not only through discovery research but also in the delivery of new interventions in diverse contexts. The overall goal of this renewal application is to strengthen the investigator base in infectious disease research in CIDEIM and other Colombian institutions and their research and training capacity to enable implementation of the results of research on these diseases into practice. This will be achieved through: a) early research career development of eight New Investigators and Junior Faculty as Global Infectious Disease (GID) Scholars and their establishment as investigators in CIDEIM and other Colombian institutions, b) continuation of mentored research and comprehensive research training of 4 Doctoral and 6 Clinical Research/MSc trainees and, c) by integrating the principles of implementation science into both our GlD research training curriculum and mentored trainee projects across the spectrum of basic to applied, biomedical, clinical and public health research. In alliance with Yale University, the committed participation of national post-graduate programs in biomedical and health sciences, together with a strong platform of funded research at CIDEIM and the ongoing research of GID program faculty, the renewal of this program will continue to create synergies with national and regional post-graduate programs in biomedical and health sciences through an integrative portfolio of post- graduate elective web-based interinstitutional courses and seminars, workshops on leadership, mentorship, and good research practices, and strategic use of communication technologies.

Public Health Relevance

Historically, Colombia has been a focal point of tropical and infectious disease research. The post-conflict strategy of the government of Colombia has prioritized development and improvement of health in rural areas impacted by over 5 decades of conflict. Communities in these areas are among the most affected by leishmaniasis and other vector-borne and emerging infectious diseases and have chronically limited access to healthcare. This training program will prepare a cohort of new investigators in CIDEIM and other Colombian institutions and strengthen their research and training capacity to enable the implementation of the results of research on these diseases, into practice.

National Institute of Health (NIH)
Fogarty International Center (FIC)
International Research Training Grants (D43)
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Special Emphasis Panel (ZRG1)
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Sina, Barbara J
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Centro Internacional (Cideim)
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Gallego-Marin, Carolina; Schrum, Jacob E; Andrade, Warrison A et al. (2018) Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria. J Immunol 200:768-774
Correa, Adriana; Del Campo, Rosa; Escandón-Vargas, Kevin et al. (2018) Distinct Genetic Diversity of Carbapenem-Resistant Acinetobacter baumannii from Colombian Hospitals. Microb Drug Resist 24:48-54
Kip, Anke E; Castro, María Del Mar; Gomez, Maria Adelaida et al. (2018) Simultaneous population pharmacokinetic modelling of plasma and intracellular PBMC miltefosine concentrations in New World cutaneous leishmaniasis and exploration of exposure-response relationships. J Antimicrob Chemother 73:2104-2111
Mera-Ramírez, Angélica; Castillo, Andrés; Orobio, Yenifer et al. (2017) Screening of TNF?, IL-10 and TLR4 single nucleotide polymorphisms in individuals with asymptomatic and chronic cutaneous leishmaniasis in Colombia: a pilot study. BMC Infect Dis 17:177
Motoa, Gabriel; Muñoz, Juan Sebastián; Oñate, José et al. (2017) Epidemiology of Candida isolates from Intensive Care Units in Colombia from 2010 to 2013. Rev Iberoam Micol 34:17-22
Barrera, Maria Claudia; Rojas, Laura Jimena; Weiss, Austin et al. (2017) Profiling gene expression of antimony response genes in Leishmania (Viannia) panamensis and infected macrophages and its relationship with drug susceptibility. Acta Trop 176:355-363
Castro, Maria Del Mar; Cossio, Alexandra; Velasco, Carlos et al. (2017) Risk factors for therapeutic failure to meglumine antimoniate and miltefosine in adults and children with cutaneous leishmaniasis in Colombia: A cohort study. PLoS Negl Trop Dis 11:e0005515
Martínez-Valencia, Alvaro J; Daza-Rivera, Carlos Frisherald; Rosales-Chilama, Mariana et al. (2017) Clinical and parasitological factors in parasite persistence after treatment and clinical cure of cutaneous leishmaniasis. PLoS Negl Trop Dis 11:e0005713
Berger, Brandon A; Cossio, Alexandra; Saravia, Nancy Gore et al. (2017) Cost-effectiveness of meglumine antimoniate versus miltefosine caregiver DOT for the treatment of pediatric cutaneous leishmaniasis. PLoS Negl Trop Dis 11:e0005459
Castro, María Del Mar; Gomez, Maria Adelaida; Kip, Anke E et al. (2017) Pharmacokinetics of Miltefosine in Children and Adults with Cutaneous Leishmaniasis. Antimicrob Agents Chemother 61:

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