Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
NIH Director’s New Innovator Awards (DP2)
Project #
1DP2OD002177-01
Application #
7429951
Study Section
Special Emphasis Panel (ZGM1-NDIA-G (07))
Program Officer
Basavappa, Ravi
Project Start
2007-09-30
Project End
2012-08-31
Budget Start
2007-09-30
Budget End
2012-08-31
Support Year
1
Fiscal Year
2007
Total Cost
$2,362,500
Indirect Cost
Name
University of Pennsylvania
Department
Biochemistry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Shorter, James (2017) Designer protein disaggregases to counter neurodegenerative disease. Curr Opin Genet Dev 44:1-8
Mack, Korrie L; Shorter, James (2016) Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity. Front Mol Biosci 3:8
Torrente, Mariana P; Chuang, Edward; Noll, Megan M et al. (2016) Mechanistic Insights into Hsp104 Potentiation. J Biol Chem 291:5101-15
Sweeny, Elizabeth A; Shorter, James (2016) Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104. J Mol Biol 428:1870-85
Lindberg, Iris; Shorter, James; Wiseman, R Luke et al. (2015) Chaperones in Neurodegeneration. J Neurosci 35:13853-9
Lump, Edina; Castellano, Laura M; Meier, Christoph et al. (2015) A molecular tweezer antagonizes seminal amyloids and HIV infection. Elife 4:
Jackrel, Meredith E; Yee, Keolamau; Tariq, Amber et al. (2015) Disparate Mutations Confer Therapeutic Gain of Hsp104 Function. ACS Chem Biol 10:2672-9
Jackrel, Meredith E; Shorter, James (2015) Engineering enhanced protein disaggregases for neurodegenerative disease. Prion 9:90-109
Castellano, Laura M; Bart, Stephen M; Holmes, Veronica M et al. (2015) Repurposing Hsp104 to Antagonize Seminal Amyloid and Counter HIV Infection. Chem Biol 22:1074-86
Sweeny, Elizabeth A; Jackrel, Meredith E; Go, Michelle S et al. (2015) The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation. Mol Cell 57:836-849

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