Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
NIH Director’s New Innovator Awards (DP2)
Project #
1DP2OD002420-01
Application #
7431122
Study Section
Special Emphasis Panel (ZGM1-NDIA-G (07))
Program Officer
Basavappa, Ravi
Project Start
2007-09-30
Project End
2012-08-31
Budget Start
2007-09-30
Budget End
2012-08-31
Support Year
1
Fiscal Year
2007
Total Cost
$2,317,500
Indirect Cost
Name
University of California San Diego
Department
Pharmacology
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Wei, Spencer C; Fattet, Laurent; Tsai, Jeff H et al. (2015) Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol 17:678-88
Chang, Andrew T; Liu, Yuanjie; Ayyanathan, Kasirajan et al. (2015) An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors. Genes Dev 29:603-16
Paz, H; Pathak, N; Yang, J (2014) Invading one step at a time: the role of invadopodia in tumor metastasis. Oncogene 33:4193-202
Tsai, Jeff H; Yang, Jing (2013) Epithelial-mesenchymal plasticity in carcinoma metastasis. Genes Dev 27:2192-206
Low-Marchelli, Janine M; Ardi, Veronica C; Vizcarra, Edward A et al. (2013) Twist1 induces CCL2 and recruits macrophages to promote angiogenesis. Cancer Res 73:662-71
Tsai, Jeff H; Donaher, Joana Liu; Murphy, Danielle A et al. (2012) Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22:725-36
Goodnough, L Henry; Chang, Andrew T; Treloar, Charles et al. (2012) Twist1 mediates repression of chondrogenesis by ?-catenin to promote cranial bone progenitor specification. Development 139:4428-38
Kopp, Janel L; von Figura, Guido; Mayes, Erin et al. (2012) Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell 22:737-50
Eckert, Mark A; Lwin, Thinzar M; Chang, Andrew T et al. (2011) Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell 19:372-86
Eckert, Mark A; Yang, Jing (2011) Targeting invadopodia to block breast cancer metastasis. Oncotarget 2:562-8