Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Fellowships (FIC) (F05)
Project #
3F05TW003435-01S1
Application #
3020619
Study Section
(BI)
Project Start
1985-07-01
Project End
Budget Start
1985-07-01
Budget End
1985-12-31
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Nakamura, K; Kusuoka, H; Ambrosio, G et al. (1993) Glycolysis is necessary to preserve myocardial Ca2+ homeostasis during beta-adrenergic stimulation. Am J Physiol 264:H670-8
Ambrosio, G; Flaherty, J T (1992) Effects of the superoxide radical scavenger superoxide dismutase, and of the hydroxyl radical scavenger mannitol, on reperfusion injury in isolated rabbit hearts. Cardiovasc Drugs Ther 6:623-32
Ambrosio, G; Zweier, J L; Flaherty, J T (1991) The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion. J Mol Cell Cardiol 23:1359-74
Ambrosio, G; Weisman, H F; Mannisi, J A et al. (1989) Progressive impairment of regional myocardial perfusion after initial restoration of postischemic blood flow. Circulation 80:1846-61
Laster, S B; Becker, L C; Ambrosio, G et al. (1989) Reduced aerobic metabolic efficiency in globally ""stunned"" myocardium. J Mol Cell Cardiol 21:419-26
Ambrosio, G; Weisfeldt, M L; Jacobus, W E et al. (1987) Evidence for a reversible oxygen radical-mediated component of reperfusion injury: reduction by recombinant human superoxide dismutase administered at the time of reflow. Circulation 75:282-91
Ambrosio, G; Zweier, J L; Jacobus, W E et al. (1987) Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: the role of iron in the pathogenesis of reperfusion injury. Circulation 76:906-15
Stahl, L D; Aversano, T; Ambrosio, G et al. (1987) Effect of repeated episodes of drug-induced ventricular dyskinesia on subsequent regional function in the dog: comparison with myocardial stunning produced by repeated coronary occlusions. J Am Coll Cardiol 9:1339-47
Ambrosio, G; Jacobus, W E; Bergman, C A et al. (1987) Preserved high energy phosphate metabolic reserve in globally ""stunned"" hearts despite reduction of basal ATP content and contractility. J Mol Cell Cardiol 19:953-64
Ambrosio, G; Becker, L C; Hutchins, G M et al. (1986) Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury. Circulation 74:1424-33