Through the combination of reversible inactivation and electroencephalography (EEG), we propose to parse the separate functions of the cerebellar cortex and nucleus in the acquisition of learned responses in rabbit eyelid conditioning. Then, building upon the technical knowledge gained from this first study, we propose to use multi-wire electrodes to make unit recordings of Purkinje neurons in order to determine how their firing patterns change in response to acquisition of conditioned responses. By providing a measure of learning separate from conditioned response performance, this would allow us to investigate the cortical and nuclear interactions that produce acquisition, extinction and savings with much greater resolution than has previously been possible.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31MH069068-01
Application #
6694728
Study Section
Special Emphasis Panel (ZRG1-F02A (20))
Program Officer
Desmond, Nancy L
Project Start
2003-09-01
Project End
2006-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
1
Fiscal Year
2003
Total Cost
$26,544
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Neurosciences
Type
Schools of Medicine
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225