Several lines of evidence indicate monoaminergic neurotransmission, environmental stress and their interaction play prominent roles in depression etiology. This project will investigate this process in adolescents and young adults by modeling the direct and interactive effects of environmental risk and candidate genes influencing neurotransmission. Using the National Longitudinal Study of Adolescent Health, mixed regression models will extend existing cross-sectional models through comprehensive examination of several candidate genes and more nuanced conceptualization of environmental risk. Further, using latent curve models, longitudinal analyses of main effects, epistasis and gene-environment interaction (GxE) among candidate genes and environmental risk will model trajectories of depression across adolescence and into young adulthood. Proximate and distal environmental risk will be distinguished and the degree to which proximate environmental factors moderate the main and GxE effects of distal factors will be assessed. Finally, as genetic architecture and social influences may vary by group, effect heterogeneity will be examined by stratifying all analyses by race/ethnicity and gender. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31MH079653-01
Application #
7223014
Study Section
Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Curvey, Mary F
Project Start
2006-11-16
Project End
2007-05-31
Budget Start
2006-11-16
Budget End
2007-05-31
Support Year
1
Fiscal Year
2006
Total Cost
$17,669
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Social Sciences
Type
Schools of Arts and Sciences
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Adkins, Daniel E; Aberg, Karolina; McClay, Joseph L et al. (2010) A genomewide association study of citalopram response in major depressive disorder-a psychometric approach. Biol Psychiatry 68:e25-7