Abstract

The central focus of my NRSA proposal is to examine the role neuropeptide (NPY) Y1 receptor deletion has on models of ethanol relapse such as the alcohol deprivation effect and ethanol reinstatement behavior under extinction. Under the direct supervision of Dr. Todd Thiele, I will have access to NPY Y1 mutant mice (Y1R-/-) which I will use to address the role of this receptor in ethanol relapse.
The first aim will focus on the effect that Y1 receptor deletion has on uncontrolled ethanol drinking as modeled by the alcohol deprivation effect. A further inquiry will test whether footshock stress enhances the alcohol deprivation effect in Y1R-/- mice compared to Y1R+/+ controls. The second specific aim will explore whether Y1 R-/- mice show enhanced ethanol reinstatement behavior following ethanol extinction compared to Y1R+/+ mice. Together these experiments will provide an important characterization of the NPY Y1 receptor on two well-established models of ethanol relapse behavior. Further, the results from these investigations can potentially provide novel neurobiological targets for the treatment of alcoholism in human populations. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32AA015878-01
Application #
6998597
Study Section
Special Emphasis Panel (ZAA1-HH (30))
Program Officer
Egli, Mark
Project Start
2005-09-01
Project End
2006-07-18
Budget Start
2005-09-01
Budget End
2006-07-18
Support Year
1
Fiscal Year
2005
Total Cost
$39,543
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Sparta, Dennis R; Ferraro 3rd, Frank M; Fee, Jon R et al. (2009) The alcohol deprivation effect in C57BL/6J mice is observed using operant self-administration procedures and is modulated by CRF-1 receptor signaling. Alcohol Clin Exp Res 33:31-42
Sparta, Dennis R; Sparrow, Angela M; Lowery, Emily G et al. (2008) Blockade of the corticotropin releasing factor type 1 receptor attenuates elevated ethanol drinking associated with drinking in the dark procedures. Alcohol Clin Exp Res 32:259-65
Sparta, Dennis R; Fee, Jon R; Knapp, Darin J et al. (2007) Elevated anxiety-like behavior following ethanol exposure in mutant mice lacking neuropeptide Y (NPY). Drug Alcohol Depend 90:297-300
Ferraro 3rd, Frank M; Sparta, Dennis R; Knapp, Darin J et al. (2006) Increased consumption but not operant self-administration of ethanol in mice lacking the RIIbeta subunit of protein kinase A. Alcohol Clin Exp Res 30:825-35