Benign Prostatic Hyperplasia (BPH) and Chronic Kidney Disease (CKD) are both common medical conditions in aging men. Prior studies looking at the association between these two diseases have been case series of 3PH patients at the time of intervention, often confounded by acute urinary retention. BPH and its urinary tract infection (UTI) complication may be under-appreciated risk factors for the development of CKD. This study will use data from a community-based prospective longitudinal cohort study of 2311 men followed for complications of BPH over 13 years. Using both a linear mixed effects regression model and a logistic regression model, the relationship between a baseline BPH surrogate measure and/or UTI history with the development of CKD will be assessed. Baseline BPH surrogate measures are a symptom score, peak urinary flow rate, residual urine volume, and prostate size. Development of CKD will be assessed through biennial longitudinal changes in serum creatinine. Known risk factors for CKD such as diabetes mellitus and hypertension will be abstracted from the medical record and adjusted for as potential confounders. Based on preliminary data, a significant association between BPH surrogate measures and CKD is expected. This study will clarify whether earlier assessment and intervention in BPH is warranted to prevent CKD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32DK068996-01
Application #
6836124
Study Section
Special Emphasis Panel (ZRG1-HOP-L (90))
Program Officer
Rankin, Tracy L
Project Start
2004-09-01
Project End
2005-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
1
Fiscal Year
2004
Total Cost
$54,692
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
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Rule, Andrew D; Jacobsen, Steven J; Schwartz, Gary L et al. (2006) A comparison of serum creatinine-based methods for identifying chronic kidney disease in hypertensive individuals and their siblings. Am J Hypertens 19:608-14
Rule, Andrew D; Rodeheffer, Richard J; Larson, Timothy S et al. (2006) Limitations of estimating glomerular filtration rate from serum creatinine in the general population. Mayo Clin Proc 81:1427-34
Rule, A D; Bergstralh, E J; Slezak, J M et al. (2006) Glomerular filtration rate estimated by cystatin C among different clinical presentations. Kidney Int 69:399-405
Rule, Andrew D; Jacobson, Debra J; McGree, Michaela E et al. (2005) Longitudinal changes in post-void residual and voided volume among community dwelling men. J Urol 174:1317-21; discussion 1321-2; aut
Rule, Andrew D; Lieber, Michael M; Jacobsen, Steven J (2005) Is benign prostatic hyperplasia a risk factor for chronic renal failure? J Urol 173:691-6