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Studies on Ribonucleotide Reductase Inactivation
Ashley, Gary W.   
University of Wisconsin Madison, Madison, WI, United States


  Search 13 grants from Gary Ashley
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  Abstract

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32GM010226-02
Application #
3040169
Study Section
(BI)
Project Start
1985-09-01
Project End
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
Earth Sciences/Resources
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Ashley, G W; Harris, G; Stubbe, J A (1988) Inactivation of the ribonucleoside triphosphate reductase from Lactobacillus leichmannii by 2'-chloro-2'-deoxyuridine 5'-triphosphate: a 3'-2' hydrogen transfer during the formation of 3'-keto-2'-deoxyuridine 5'-triphosphate. Biochemistry 27:7841-5
Ashley, G W; Harris, G; Stubbe, J (1988) Inactivation of the Lactobacillus leichmannii ribonucleoside triphosphate reductase by 2'-chloro-2'-deoxyuridine 5'-triphosphate: stoichiometry of inactivation, site of inactivation, and mechanism of the protein chromophore formation. Biochemistry 27:4305-10
Harris, G; Ashley, G W; Robins, M J et al. (1987) 2'-Deoxy-2'-halonucleotides as alternate substrates and mechanism-based inactivators of Lactobacillus leichmannii ribonucleotide reductase. Biochemistry 26:1895-902

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