? The objective of the research proposal is the design and development of a convergent and efficient strategy for the synthesis of the anti-inflammatory agent, rameswaralide. The preparation of rameswaralide and any analogues would advance their development as potential therapeutic agents for the treatment of a wide variety of inflammatory disorders such as arthritis, psoriasis, and inflammatory bowel disease. The proposed synthesis highlights both a ruthenium-catalyzed [5+2] cycloaddition and a direct catalytic enantioselective aldol reaction as key steps. The successful application of these methods in complex synthesis would provide flexible and practical route for constructing biologically important molecules that are structurally similar to rameswaralide. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32GM073300-01A1
Application #
6880378
Study Section
Special Emphasis Panel (ZRG1-F04A (20))
Program Officer
Fabian, Miles
Project Start
2005-09-01
Project End
2006-07-14
Budget Start
2005-09-01
Budget End
2006-07-14
Support Year
1
Fiscal Year
2005
Total Cost
$37,479
Indirect Cost
Name
Stanford University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305